Francisco Cammarata‐ScalisiMichele CalleaDianora AraqueMaría Angelina Lacruz-RengelGloria Da SilvaRodolfo Josué RamírezFabiola López2026-03-222026-03-222015https://dialnet.unirioja.es/servlet/oaiart?codigo=5191687https://andeanlibrary.org/handle/123456789/61772Wolf-Hirschhorn syndrome is a genetic entity produced by a partial deletion spanning the distal short arm of chromosome 4(4p16.3). The most common manifestations are craniofacial anomalies, psychomotor retardation and neurological disorders. The estimated incidence is 1 in 50,000 births, although there is an underdiagnosis of this entity. The aim of this study is to describe four clinical cases of Wolf-Hirschhorn syndrome with specific description of clinical and cytogenetic findings.enarticle