Roberto LanesPeter GünczlerJesús A. OsunaAnselmo PalaciosEduardo CarrilloXiomara RamirezCoromoto GarciaMariela PaoliOmar Villaroel2026-03-222026-03-22199710.1159/000185421https://doi.org/10.1159/000185421https://andeanlibrary.org/handle/123456789/52069Citaciones: 32In order to evaluate the effectiveness of the gonadotropin-releasing hormone agonist leuprolide acetate in distinguishing gonadotropin deficiency from delayed puberty, a single subcutaneous dose of 20 micrograms/kg of leuprolide acetate was administered at 07.00 h to 14 patients with constitutionally delayed puberty and to 8 gonadotropin-deficient subjects, and serum gonadotropin and testosterone levels were determined at baseline and 1,2,3,6,12, and 24 h thereafter. The increase in gonadotropin and testosterone levels was significant in patients with delayed puberty, so that the mean peak luteinizing hormone and to a lesser degree the mean peak testosterone levels clearly differentiated normally delayed from gonadotropin-deficient puberty. However, when the peak gonadotropin and testosterone concentrations were analyzed individually, there was a considerable overlap between the two groups of males, limiting the usefulness of this test.enInternal medicineEndocrinologyGonadotropinTestosterone (patch)Gonadotropin-releasing hormone agonistLuteinizing hormoneGonadotropin-releasing hormoneAgonistMedicineHormonearticle