Apaza Ticona, LSiñani Callisaya, G BAguilar Rico, FSánchez Sánchez-Corral, JSlowing, K2026-03-242026-03-2420221478-6427PMID:3500716910.1080/14786419.2022.2025593https://doi.org/10.1080/14786419.2022.2025593https://andeanlibrary.org/handle/123456789/100982Vol. 36, No. 24, pp. 6324-6328Buddleja coriacea (B. coriacea) commonly known as 'Kiswara' is used as infusions for stomach and joint pain. This study aims to evaluate the in vitro and in vivo anti-inflammatory and anti-arthritic activity was evaluated by measuring inflammatory parameters (TNF-α, C-reactive protein and Fibrinogen) in murine models of the aqueous extract and isolated compounds of B. coriacea. A bio-guided phytochemical analysis based on NMR/MS was performed identifying three (1-3) compounds of the aqueous extract. All compounds inhibited the production of TNF-α in RAW 264.7 cell line, with IC50 of 13.44 (1), 1.13 (2) and 0.57 μM (3), respectively. In addition, compounds 2 and 3 decreased the levels of TNF-α, C-reactive protein and fibrinogen at a concentration of 5 mg/kg in murine models. Our research shows that the compounds isolated from B. coriacea have anti-inflammatory and anti-arthritic properties, providing scientific evidence for the traditional use of this plant species.engBuddleja coriaceaLoganiaceaeTNF-αanti-arthriticanti-inflammatoryArtículo Científico Publicado