Patricia V. AguilarAmy C. MorrisonClaudio RochaDouglas M. WattsLuis BeingoleaVíctor SuárezJorge VargasCristhopher D. CruzCarolina GuevaraJoel M. Montgomery2026-03-222026-03-22201010.4269/ajtmh.2010.10-0116https://doi.org/10.4269/ajtmh.2010.10-0116https://andeanlibrary.org/handle/123456789/48225Citaciones: 26Guaroa virus (GROV) was first isolated from humans in Colombia in 1959. Subsequent isolates of the virus have been recovered from febrile patients and mosquitoes in Brazil, Colombia, and Panama; however, association of the virus with human disease has been unclear. As part of a study on the etiology of febrile illnesses in Peru and Bolivia, 14 GROV strains were isolated from patients with febrile illnesses, and 3 additional cases were confirmed by IgM seroconversion. The prevalence rate of GROV antibodies among Iquitos residents was 13%; the highest rates were among persons with occupations such as woodcutters, fisherman, and oil-field workers. Genetic characterization of representative GROV isolates indicated that strains from Peru and Bolivia form a monophyletic group that can be distinguished from strains isolated earlier in Brazil and Colombia. This study confirms GROV as a cause of febrile illness in tropical regions of Central and South America.enSeroconversionEtiologyVirusPanamaLatin AmericansVirologyMedicineBiologyarticle