Stacy ZamudioTatiana TorricosEwa FikMaria OyalaLourdes EchalarJanet PullockaranEmily TutinoBrittney MartinSonia BelliappaElfride Balanza2026-03-222026-03-22200910.1371/journal.pone.0008551https://doi.org/10.1371/journal.pone.0008551https://andeanlibrary.org/handle/123456789/43264Citaciones: 139Our results support that preferential anaerobic consumption of glucose by the placenta at high altitude spares oxygen for fetal use, but limits glucose availability for fetal growth. Thus reduced fetal growth at high altitude is associated with fetal hypoglycemia, hypoinsulinemia and a trend towards lactacidemia. Our data support that placentally-mediated reduction in glucose transport is an initiating factor for reduced fetal growth under conditions of chronic hypoxemia.enFetusInternal medicineEndocrinologyPregnancyGlucose transporterPlacentaIntrauterine growth restrictionPlacental insufficiencyGlucose uptakeHypoxia (environmental)article