Miguel Guzmán-Rivero2026-03-222026-03-22202310.32388/0hj7sshttps://doi.org/10.32388/0hj7sshttps://andeanlibrary.org/handle/123456789/86985Potential competing interests: No potential competing interests to declare.The manuscript is interesting.In my opinion, it provides compelling evidence on the appearance of new variants in the context of the SARS-CoV-2 pandemic, supported by the selection-limited hypothesis rather than the mutation-limited one.The knowledge in this regard should allow effective control actions to be taken in future pandemics.I reccomend itsenSelection (genetic algorithm)PandemicSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus disease 2019 (COVID-19)Mutation2019-20 coronavirus outbreakBiologyVirologyGeneticsComputational biologyReview of: "Evolution of new variants of SARS-CoV-2 during the pandemic: mutation-limited or selection-limited?"peer-review