Browsing by Autor "Daniel Eid Rodríguez"

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Arterial Stiffness in Heart‐Healthy Indigenous Tsimane Forager‐Horticulturalists
(Wiley, 2025) Tianyu Cao; Edhitt Cortez Linares; Raúl Quispe Gutierrez; Daniel Eid Rodríguez; Juana Bani Cuata; Michael I. Miyamoto; Christopher von Rueden; Daniel K. Cummings; Paul L. Hooper; Benjamin C. Trumble
Tsimane forager-farmers of the Bolivian Amazon demonstrate substantially lower arterial stiffness throughout adulthood than more urbanized and sedentary populations, and the differences are only partially explained by conventional cardiometabolic risk factors.
Assessment of a Leishmaniasis Reporting System in Tropical Bolivia Using the Capture-Recapture Method
(American Society of Tropical Medicine and Hygiene, 2017) Daniel Eid Rodríguez; Miguel Guzmán-Rivero; Ernesto Rojas; Isabel Goicolea; Anna‐Karin Hurtig; Daniel Illanes; Miguel San Sebastiån
This study evaluates the level of underreporting of the National Program of Leishmaniasis Control (NPLC) in two communities of Cochabamba, Bolivia during the period 2013-2014. Montenegro skin test-confirmed cases of cutaneous leishmaniasis (CL) were identified through active surveillance during medical campaigns. These cases were compared with those registered in the NPLC by passive surveillance. After matching and cleaning data from the two sources, the total number of cases and the level of underreporting of the National Program were calculated using the capture-recapture analysis. This estimated that 86 cases of CL (95% confidence interval [CI]: 62.1-110.8) occurred in the study period in both communities. The level of underreporting of the NPLC in these communities was very high: 73.4% (95% CI: 63.1-81.5%). These results can be explained by the inaccessibility of health services and centralization of the NPLC activities. This information is important to establish priorities among policy-makers and funding organizations as well as implementing adequate intervention plans.
“Cheaper and better”: Societal cost savings and budget impact of changing from systemic to intralesional pentavalent antimonials as the first-line treatment for cutaneous leishmaniasis in Bolivia
(Public Library of Science, 2019) Daniel Eid Rodríguez; Miguel San Sebastiån; Anni‐Maria Pulkki‐Brännström
The results of this study support a shift to ILPA as the first-line treatment for CL in Bolivia and possibly in other South American countries.
Childhood skeletal lesions common in prehistory are present in living forager-farmers and predict adult markers of immune function
(American Association for the Advancement of Science, 2025) Amy Anderson; Aaron D. Blackwell; M Linda Sutherland; Thomas S. Kraft; J. D. Sutherland; Bret Beheim; Daniel K. Cummings; Suhail Ghafoor; Paul L. Hooper; Daniel Eid Rodríguez
Porous cranial lesions (cribra cranii and cribra orbitalia) are widely used by archaeologists as skeletal markers of poor child health. However, their use has not been validated with systematic data from contemporary populations, where there has been little evidence of these lesions or their health relevance. Using 375 in vivo computed tomography scans from a cohort-representative sample of adults aged 40+ years from the Bolivian Amazon, among food-limited, high-mortality forager-farmers, we identified cribra cranii on 46 (12.3%) and cribra orbitalia on 23 (6%). Cribra orbitalia was associated with several hallmarks of compromised immune function, including fewer B cells, fewer naïve CD4+ T cells, a lower CD4+/CD8+ T cell ratio, and higher tuberculosis risk. However, neither lesion type predicted other physician-diagnosed respiratory diseases, other markers of cell-mediated immunity, or hemoglobin values. While cribra orbitalia shows promise as a skeletal indicator of health challenges, our findings do not support the continued practice of using these lesions to infer anemia in adults.
Conocimientos, prácticas y seroprevalencia humana de brucelosis en la zona lechera central de Cochabamba, Bolivia
(Pan American Health Organization, 2025) Rosse Mary Yañez; Rocío Quitón; Ernesto Rojas; Tania Vargas; Daniel Eid Rodríguez; Jean‐Jacques Letesson; Patricia Rodríguez
This study revealed a high seroprevalence of brucellosis in the La Maica dairy-producing area in Cochabamba (Plurinational State of Bolivia), with many asymptomatic cases and a high number of false positives from IgG indirect ELISA. It is recommended to conduct awareness-raising campaigns on the risks of this disease and to discourage the consumption of raw milk.
Correction to: risk factors for cutaneous leishmaniasis in the rainforest of Bolivia: a cross-sectional study
(BioMed Central, 2018) Daniel Eid Rodríguez; Miguel Guzmán-Rivero; Ernesto Rojas; Isabel Goicolea; Anna‐Karin Hurtig; Daniel Illanes; Miguel San Sebastiån
Does Blood Pressure Inevitably Rise With Age?
(Lippincott Williams & Wilkins, 2012) Michael Gurven; Aaron D. Blackwell; Daniel Eid Rodríguez; Jonathan Stieglitz; Hillard Kaplan
The rise in blood pressure with age is a major risk factor for cardiovascular and renal disease, stroke, and type 2 diabetes mellitus. Age-related increases in blood pressure have been observed in almost every population, except among hunter-gatherers, farmers, and pastoralists. Here we tested for age-related increases in blood pressure among Tsimane forager-farmers. We also test whether lifestyle changes associated with modernization lead to higher blood pressure and a greater rate of age-related increase in blood pressure. We measured blood pressure longitudinally on 2248 adults age ≥ 20 years (n=6468 observations over 8 years). Prevalence of hypertension was 3.9% for women and 5.2% for men, although diagnosis of persistent hypertension based on multiple observations reduced prevalence to 2.9% for both sexes. Mixed-effects models revealed systolic, diastolic, and pulse blood pressure increases of 2.86 (P<0.001), 0.95 (P<0.001), and 1.95 mmHg (P<0.001) per decade for women and 0.91 (P<0.001), 0.93 (P<0.001), and -0.02 mmHg (P=0.93) for men, substantially lower than rates found elsewhere. Lifestyle factors, such as smoking and Spanish fluency, had minimal effect on mean blood pressure and no effect on age-related increases in blood pressure. Greater town proximity was associated with a lower age-related increase in pulse pressure. Effects of modernization were, therefore, deemed minimal among Tsimane, in light of their lean physique, active lifestyle, and protective diet.
Engaging Communities in Health Promotion through Community-Based Primary Care and Participatory Research During the COVID-19 Pandemic in Bolivia
(Elsevier BV, 2025) Christine Leyns; Carla Ascarrunz; Shirley Rasguido; Patricia Rodríguez; Daniel Eid Rodríguez; Javier Guitián
Geographical inequities in cervical cancer screening coverage in Bolivia: a spatial nationwide ecological study
(Pan American Health Organization, 2025) Carla Huanca Challgua; Ida Linander; Isabel Goicolea; Daniel Eid Rodríguez; Osvaldo Fonseca‐Rodríguez
Bolivia is still a long way from achieving the World Health Organization target of 70% screening coverage. The present results indicate where the screening program must be reinforced to improve the responsiveness of Bolivia's health system to women's reproductive health needs.
Health costs of reproduction are minimal despite high fertility, mortality and subsistence lifestyle
(Nature Portfolio, 2016) Michael Gurven; Megan Costa; Benjamin C. Trumble; Jonathan Stieglitz; Bret Beheim; Daniel Eid Rodríguez; Paul L. Hooper; Hillard Kaplan
Hybrid, Vaccine-Induced and Natural Immunity Against Sars-Cov-2 in Traditional Food Markets in Bolivia (2020-2022): A Cross-Sectional Analysis of a Serological Survey
(RELX Group (Netherlands), 2024) Christine Leyns; Elliot McClenaghan; Patricia Rodríguez; Patrick Nguipdop‐Djomo; Carla Ascarrunz; Daniel Eid Rodríguez; Punam Mangtani; Javier Guitián
Hybrid, Vaccine-Induced and Natural Immunity Against SARS-CoV-2 in Traditional Food Markets in Bolivia (2020-2022): A Cross-Sectional Analysis of a Serological Survey
(RELX Group (Netherlands), 2024) Christine Leyns; Elliot McClenaghan; Patricia Rodríguez; Patrick Nguipdop‐Djomo; Carla Ascarrunz; Daniel Eid Rodríguez; Punam Mangtani; Javier Guitián
Hybrid, vaccine-induced and natural immunity against SARS-CoV-2 in traditional food markets in Bolivia (2020−2022): A cross-sectional analysis of a serological survey
(Elsevier BV, 2025) Christine Leyns; Elliot McClenaghan; Patricia Rodríguez; Patrick Nguipdop‐Djomo; Carla Ascarrunz; Daniel Eid Rodríguez; Punam Mangtani; Javier Guitián
APOE4 is associated with elevated blood lipids and lower levels of innate immune biomarkers in a tropical Amerindian subsistence population
(2021) Angela R. García; Caleb E. Finch; Margaret Gatz; Thomas S. Kraft; Daniel K. Cummings; Mia Charifson; Daniel Eid Rodríguez; Kenneth H. Buetow; Bret Beheim; Hooman Allayee
Abstract In post-industrial settings, APOE4 is associated with increased cardiovascular and neurological disease risk. However, the majority of human evolutionary history occurred in environments with higher pathogenic diversity and low cardiovascular risk. We hypothesize that in high-pathogen and energy-limited contexts, the APOE4 allele confers benefits by reducing baseline innate inflammation when uninfected, while maintaining higher lipid levels that buffer costs of immune activation during infection. Among Tsimane forager-farmers of Bolivia (N=1266), APOE4 is associated with 30% lower C-reactive protein, and higher total cholesterol and oxidized-LDL. Blood lipids were either not associated, or negatively associated with inflammatory biomarkers, except for associations of oxidized-LDL and inflammation which were limited to obese adults. Further, APOE4 carriers maintain higher levels of total and LDL cholesterol at low BMIs. These results suggest the relationship between APOE4 and lipids is likely beneficial for pathogen-driven immune responses, and unlikely to increase cardiovascular risk in an active subsistence population.
Apolipoprotein- ε 4 is associated with higher fecundity in a natural fertility population
(American Association for the Advancement of Science, 2023) Benjamin C. Trumble; Mia Charifson; Thomas S. Kraft; Angela R. García; Daniel K. Cummings; Paul L. Hooper; Amanda J. Lea; Daniel Eid Rodríguez; Stephanie V. Koebele; Kenneth H. Buetow
In many populations, the apolipoprotein-ε4 (APOE-ε4) allele increases the risk for several chronic diseases of aging, including dementia and cardiovascular disease; despite these harmful effects at later ages, the APOE-ε4 allele remains prevalent. We assess the impact of APOE-ε4 on fertility and its proximate determinants (age at first reproduction, interbirth interval) among the Tsimane, a natural fertility population of forager-horticulturalists. Among 795 women aged 13 to 90 (20% APOE-ε4 carriers), those with at least one APOE-ε4 allele had 0.3 to 0.5 more children than (ε3/ε3) homozygotes, while those with two APOE-ε4 alleles gave birth to 1.4 to 2.1 more children. APOE-ε4 carriers achieve higher fertility by beginning reproduction 0.8 years earlier and having a 0.23-year shorter interbirth interval. Our findings add to a growing body of literature suggesting a need for studies of populations living in ancestrally relevant environments to assess how alleles that are deleterious in sedentary urban environments may have been maintained by selection throughout human evolutionary history.
Indirect genetic effects among neighbors promote cooperation and accelerate adaptation in a small-scale human society
(American Association for the Advancement of Science, 2025) Jordan S. Martin; Bret Beheim; Michael Gurven; Hillard Kaplan; Jonathan Stieglitz; Benjamin C. Trumble; Paul L. Hooper; Daniel K. Cummings; Daniel Eid Rodríguez; Adrian V. Jaeggi
Explaining the rapid evolution of human cooperation and its role in our species' biodemographic success remains a major evolutionary puzzle. To address this challenge, we tested a social drive hypothesis, which predicts that social plasticity and social selection in human groups cause indirect genetic effects that accelerate the adaptation of fitness, promoting population growth via feedback between the environmental causes and evolutionary consequences of cooperation. Using Bayesian multilevel models to analyze fertility data from a small-scale society, we demonstrate that density- and frequency-dependent indirect genetic effects on fitness promote the evolution of cooperation among neighboring women, increasing the rate of contemporary adaptation by ~5×. Our results show how interactions between the genetic and socioecological processes shaping cooperation in reproduction can drive rapid growth and social evolution in human populations.
Inflammaging is minimal among forager-horticulturalists in the Bolivian Amazon
(Royal Society, 2025) Jacob E. Aronoff; Carrie L. Jenkins; Angela R. García; Stephanie V. Koebele; Suhail Ghafoor; Kate L. Woolard; Mia Charifson; Ivan Maldonado Suarez; Daniel Eid Rodríguez; Bret Beheim
An increase in chronic systemic inflammation in later life, termed inflammaging, is implicated in health risk. However, it is unclear whether inflammaging develops in all human populations, or if it is the product of environmental mismatch. We assessed inflammaging in Tsimane forager-horticulturalists of the Bolivian Amazon, using serum cytokines in a primarily cross-sectional sample (1134 samples from n = 714 individuals, age 39-94, 51.3% female). IL-6 was positively associated with age (β = 0.013, p < 0.01). However, other pro-inflammatory markers, including IL-1β and TNF-α, did not increase with age (β = -0.005 and β = -0.001, respectively). We then compared the Moseten, a neighbouring population that has experienced greater market integration (423 samples from n = 380 individuals, age 39-85, 48.2% female). The Moseten also showed a positive age association for IL-6 that attenuated at later ages (age β = 0.025, p < 0.01; age2 β = -0.001, p < 0.05). Further, IL-1β and TNF-α were both positively associated with age (β = 0.021, p < 0.05 and β = 0.011, p < 0.01, respectively). Our results demonstrate minimal inflammaging in the Tsimane, highlighting variation across populations in this age-related process. They also suggest that inflammaging is exacerbated by lifestyle shifts.
Inflammation and Infection Do Not Promote Arterial Aging and Cardiovascular Disease Risk Factors among Lean Horticulturalists
(Public Library of Science, 2009) Michael Gurven; Hillard Kaplan; Jeffrey Winking; Daniel Eid Rodríguez; Sarinnapha M. Vasunilashorn; Jung Ki Kim; Caleb E. Finch; Eileen M. Crimmins
Inflammation may not always be a risk factor for arterial degeneration and CVD, but instead may be offset by other factors: healthy metabolism, active lifestyle, favorable body mass, lean diet, low blood lipids and cardiorespiratory health. Other possibilities, including genetic susceptibility and the role of helminth infections, are discussed. The absence of PAD and CVD among Tsimane parallels anecdotal reports from other small-scale subsistence populations and suggests that chronic vascular disease had little impact on adult mortality throughout most of human evolutionary history.
Leishmaniasis patients' pilgrimage to access health care in rural Bolivia: a qualitative study using human rights to health approach
(BioMed Central, 2019) Daniel Eid Rodríguez; Miguel San Sebastiån; Anna‐Karin Hurtig; Isabel Goicolea
Metapopulation dynamics of SARS-CoV-2 transmission in a small-scale Amazonian society
(Public Library of Science, 2023) Thomas S. Kraft; Edmond Seabright; Sarah Alami; Samuel M. Jenness; Paul L. Hooper; Bret Beheim; Helen Davis; Daniel K. Cummings; Daniel Eid Rodríguez; Maguin Gutierrez Cayuba
The severity of infectious disease outbreaks is governed by patterns of human contact, which vary by geography, social organization, mobility, access to technology and healthcare, economic development, and culture. Whereas globalized societies and urban centers exhibit characteristics that can heighten vulnerability to pandemics, small-scale subsistence societies occupying remote, rural areas may be buffered. Accordingly, voluntary collective isolation has been proposed as one strategy to mitigate the impacts of COVID-19 and other pandemics on small-scale Indigenous populations with minimal access to healthcare infrastructure. To assess the vulnerability of such populations and the viability of interventions such as voluntary collective isolation, we simulate and analyze the dynamics of SARS-CoV-2 infection among Amazonian forager-horticulturalists in Bolivia using a stochastic network metapopulation model parameterized with high-resolution empirical data on population structure, mobility, and contact networks. Our model suggests that relative isolation offers little protection at the population level (expected approximately 80% cumulative incidence), and more remote communities are not conferred protection via greater distance from outside sources of infection, due to common features of small-scale societies that promote rapid disease transmission such as high rates of travel and dense social networks. Neighborhood density, central household location in villages, and household size greatly increase the individual risk of infection. Simulated interventions further demonstrate that without implausibly high levels of centralized control, collective isolation is unlikely to be effective, especially if it is difficult to restrict visitation between communities as well as travel to outside areas. Finally, comparison of model results to empirical COVID-19 outcomes measured via seroassay suggest that our theoretical model is successful at predicting outbreak severity at both the population and community levels. Taken together, these findings suggest that the social organization and relative isolation from urban centers of many rural Indigenous communities offer little protection from pandemics and that standard control measures, including vaccination, are required to counteract effects of tight-knit social structures characteristic of small-scale populations.