Browsing by Autor "Gérard Sevilla Encinas"

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Efecto de un esquema de recuperación nutricional a domicilio en la respuesta inmunitaria y desarrollo psicomotor en niños desnutridos leves y moderados entre seis meses y cinco años de edad.
(2013) Sevilla Paz Soldán; Mayra Arce; Rojas Odilia; Lourdes Zalles Cueto; Gérard Sevilla Encinas
Objectives: To determine the influence of malnutrition mild / moderate in immunity, psychomotor development of children from six months to five years and the effect of nutritional recovery scheme at home. Methods: A prospective randomized comparative study conducted on 1,200 children , according to inclusion and exclusion criteria. Admitted 39 children with mild and / or moderate , they were compared with 41 healthy children. Both were followed for 22 weeks. In the study group focused on food, improving the environment , stimulation. Also received supplementation with : zinc , iron, vitamin A. In case of infection was treated according to standard protocols. The control group received normal food , not supplements. Both groups were assessed by anthropometry , clinical,psychomotor development, and immunity thymus ultrasound. In both groups was conducted information, education , nutrition communication. Results: E ighty children met entry criteria, 19 children were excluded in the study group (n = 30 ) recovered a P / T at 12 weeks (95 % ), the P / E , T / E , thickness, surface thymus recovered at 22 weeks , psychomotor development did not reach the expected threshold ; infections were 2 times per child. In 83 % improved living conditions . The control group ( n = 31 ) continued to grow, with good immunity , no infection and development within expectations. Conclusions: Malnutrition mild, moderate impact on immunity, psychomotor development. His recovery is not parallel to growth. It is possible to recover at 22 weeks immunity as is later recovery psychomotor.
Efecto del tratamiento preventivo con hierro en niños anémicos sobre la probabilidad de presentar convulsión febril
(2013) Ricardo Sevilla Paz Soldán; Maribel Santa Cruz Alcoba; Maribel Choque Barrera; Lourdes Zalles Cueto; Gérard Sevilla Encinas; Carlos Eróstegui
Objectives: this study aimed to evaluate the effect of preventive treatment with iron in anemic children on the probability of febrile seizures. Methods: a randomized study in the Hospital del Nino Manuel Ascencio Villarroel from January 2010 to December 2012, which included 205 children with anemia. Of these, 68 convulsed by fever, and 98 had other obvious cause seizures, so they were excluded from the study. Was chosen as a control group of 40 children who received preventive treatment with iron glycinate chelate. All children were determined hemoglobin levels, hemotocrito, MCV, MCHC, and the number of seizures. For statistical analysis we used SPSS version 16. Hypothesis testing was performed by the Student t. Correlation analysis was used bivariate and univariate Pearson chi-square for qualitative variables. Threshold of significance p ≤ 0.05. Results: the study group was 18.6 ± 13.6 months of age, HB of 10.6 ± 1.1 mg / dl, fever 38.9 ± 0.4 ° C, 89% of this group received no preventive treatment and presented febrile seizures, 20% convulsed twice, while in the control group age was 18.0 ± 7.8 months; HB 11.97 ± 0.4, temperature of 37.9 ° C ± 0.4 , (p <0.01). This group received preventive treatment with iron, had no seizures. Iron uptake in EG was 1.4% (n = 1) received before seizure iron, 10% (n = 7) receiving iron in a batch or partial and iron in any form received 89% (n = 61) When comparing averages, the differences were significant (p ≤ 0.001) for Hb, Hct, MCV, mean corpuscular hemoglobin and temperature between groups. Hematologic correlations in the study group were significant between sei zure, Hb, hematocrit (r = 0.569, p ≤ 0.001). Frequent infections pharyngitis were 54.4% (n = 29) which had both low hemoglobin levels. Conclusions: in preventively untreated anemic children with iron, the probability of seizure events by fever is greater.
Eficacia del agregado del zinc al suero de hidratación oral versus hidratación oral clásica sobre el estado clínico nutricional e inmunitario en el tratamiento de niños con diarrea aguda
(2014) Soldán R Sevilla Paz; Carlos Eróstegui; Lourder Zalles Cueto; Gérard Sevilla Encinas
Objetivo: determinar la eficacia del agregado del zinc en la preparacion de suero de hidratacion oral versus administracion clasica de hidratacion y su efecto en el crecimiento, estado clinico nutricional e inmunitario de ninos con diarrea aguda menores de 5 anos. Metodos: estudio experimental aleatorizado realizado en el Hospital del Nin@ Manuel Ascencio Villarroel. De 700 ninos con diarrea aguda 117 ingresaron al estudio previo consentimiento de padres: 31 conformaron el grupo estudio, 42 fueron controles (44 abandonaron); con criterios de inclusion, exclusion. El GTROCRIN (SRO+ZINC) recibio zinc 20mg/1000cc en la misma preparacion del suero y el GSROH (SRO) solucion hidratante oral hipo-osmolar aparte zinc 2mg/Kg. Se realizaron: Examen clinico, tomas de muestras para hemograma, orina, heces ademas de antropometria, cuantificacion de aporte calorico, tolerancia oral, gasto fecal y respuesta inmunitaria por ecografia de timo repetidos a diez dias. Los datos fueron procesados SPSS 19, p< 0,05; IC: 95%. Resultados: al ingreso ningun nino presento deshi-dratacion grave ni complicaciones severas, copro-parasitologicos fueron negativos 51,61% (16) GTROCRIN, 35,71 % (15) GSROH. AMEBAS: GTROCRIN: 32,25%(10); GSROH: 50%(21).GIARDIA: GTROCRIN: 12,90%(4); GSROH: 14,28%(6). AMBOS PARASITOS: GTROCRIN: 3,22% (1). Al concluir el estudio GTROCRIN: P/TZ, T/EZ, P/EZ, IMC/Z,MM,MG,SOM mejoraron (p<0,0001). Diarrea duro 4,16±1,55 (GTROCRIN) vs7, 80±1,1 dias (GSROH). GTROCRIN recibio mayor aporte calorico (P<0,0001), tolero mejor, tuvo menor gasto fecal, la diarrea cedio 81,64% (25). (p<0,001), mejoro la superficie, espesor del timo 617,52±111; 24,44±3,85vs GSROH: 453,46±74,82; 19,80±1,61 (p<<0,001) en este grupo la evolucion fue torpida en 11,9% (5) ninos.Conclusiones: el estudio muestra mayor eficacia en el tratamiento de la diarrea aguda con el agregado del zinc en suero de hidratacion oral que sin el, en la mejoria clinico-nutricional e inmunitaria.Palabras claves: diarrea aguda, SRO, zinc, clinica, inmunidad, nutricion.