Synergistic Effect of Lupenone and Caryophyllene Oxide against<i>Trypanosoma cruzi</i>
| dc.contributor.author | Glendy Polanco-Hernández | |
| dc.contributor.author | Fabiola Escalante‐Erosa | |
| dc.contributor.author | Karlina García‐Sosa | |
| dc.contributor.author | María E. Rosado | |
| dc.contributor.author | Eugenia Guzmán-Marı́n | |
| dc.contributor.author | Karla Y. Acosta-Viana | |
| dc.contributor.author | Alberto Giménez-Turba | |
| dc.contributor.author | Efraín Salamanca | |
| dc.contributor.author | Luis M. Peña-Rodrı́guez | |
| dc.coverage.spatial | Bolivia | |
| dc.date.accessioned | 2026-03-22T14:35:19Z | |
| dc.date.available | 2026-03-22T14:35:19Z | |
| dc.date.issued | 2013 | |
| dc.description | Citaciones: 21 | |
| dc.description.abstract | The in vitro trypanocidal activity of a 1 : 4 mixture of lupenone and caryophyllene oxide confirmed a synergistic effect of the terpenoids against epimastigotes forms of T. cruzi (IC50 = 10.4 μ g/mL, FIC = 0.46). In addition, testing of the terpenoid mixture for its capacity to reduce the number of amastigote nests in cardiac tissue and skeletal muscle of infected mice showed a reduction of more than 80% at a dose level of 20.8 mg·kg(-1)·day(-1). | |
| dc.identifier.doi | 10.1155/2013/435398 | |
| dc.identifier.uri | https://doi.org/10.1155/2013/435398 | |
| dc.identifier.uri | https://andeanlibrary.org/handle/123456789/47386 | |
| dc.language.iso | en | |
| dc.publisher | Hindawi Publishing Corporation | |
| dc.relation.ispartof | Evidence-based Complementary and Alternative Medicine | |
| dc.source | Secretaría de Investigación, Innovación y Educación Superior | |
| dc.subject | Terpenoid | |
| dc.subject | Trypanosoma cruzi | |
| dc.subject | Chemistry | |
| dc.title | Synergistic Effect of Lupenone and Caryophyllene Oxide against<i>Trypanosoma cruzi</i> | |
| dc.type | article |