Antiparasitic Metabolites from <i>Hyptis brevipes</i>, a Tacana Medicinal Plant

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dc.contributor.authorIvan Limachi
dc.contributor.authorClaudia Condo
dc.contributor.authorCamila Palma
dc.contributor.authorNélida Nina
dc.contributor.authorEfraín Salamanca
dc.contributor.authorJuan C. Ticona
dc.contributor.authorEnrique Udaeta
dc.contributor.authorNinoska Flores
dc.contributor.authorAlcides Serato
dc.contributor.authorNatalio Marupa
dc.coverage.spatialBolivia
dc.date.accessioned2026-03-22T15:51:48Z
dc.date.available2026-03-22T15:51:48Z
dc.date.issued2019
dc.descriptionCitaciones: 3
dc.description.abstractA bioassay screening against protozoa parasites of several Tacana medicinal plants gave Hyptis brevipes (Id'ene eidhue), traditionally used as decoction for intestinal parasites, as the most active extract. In this work we did a bioguided isolation of active constituents found in leaves. Structure elucidation was carried out by NMR spectroscopy and MS spectrometry analyses. Active constituents showed differentiated activity towards Giardia lamblia, Trypanosoma cruzi, several Leishmania strains, Plasmodium falciparum and cytotoxicity against HeLa cells. Brevipolide H (1) was the less cytotoxic and best antiparasitic, while the catechol derivative (2) the most active and cytotoxic.
dc.identifier.doi10.1177/1934578x1901400115
dc.identifier.urihttps://doi.org/10.1177/1934578x1901400115
dc.identifier.urihttps://andeanlibrary.org/handle/123456789/54853
dc.language.isoen
dc.publisherSAGE Publishing
dc.relation.ispartofNatural Product Communications
dc.sourceLund University
dc.subjectAntiparasitic
dc.subjectTrypanosoma cruzi
dc.subjectBiology
dc.subjectProtozoa
dc.subjectCytotoxicity
dc.subjectPlasmodium falciparum
dc.subjectHeLa
dc.subjectTraditional medicine
dc.subjectLeishmania
dc.subjectAntiparasitic agent
dc.titleAntiparasitic Metabolites from <i>Hyptis brevipes</i>, a Tacana Medicinal Plant
dc.typearticle

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