Asociaciones entre nefrolitiasis, citrato y otros metabolitos presentes en orina y suero de pacientes
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Gac Med Bol
Abstract
Objetivo: determinar las asociaciones entre nefrolitiasis citrato y otros metabolitos presentes en orina y suero de pacientes con el objeto de adecuar el diagnóstico en los protocolos de atención de la nefrolitiasis. Materiales y métodos: investigación descriptiva, transversal y de campo que incluyo sujetos con nefrolitiasis sin tratamiento con tiazidas, la muestra quedó conformada por 100 pacientes a quienes se realizó evaluación metabólica en orina de 24 horas y en muestras de suero sanguíneo. A los datos se les aplico estadísticos descriptivos y de dispersión y se compararon las frecuencias de las variables con Chi-cuadrado. Resultados: 93% de los pacientes con litiasis tenían hipocitraturia. La hipernatresiuria se presentó en 71,0%, la hipercloremia en 59,1%, las asociaciones más frecuentes fueron la hipercloremia mas hipernatruremia (50,5%) y la hiperuricosuria + hipernatruria (30,1%). Conclusiones: existe alta prevalencia de hipocitraturia en individuos con nefrolitiasis; la patología se puede presentar sola o asociada con hasta tres anormalidades bioquímicas de orina y suero; la hipercloremia mas la hipermagnesemia es el único dúo de factores sanguíneos que caracteriza al paciente con nefrolitiasis e hipocitraturia; y es frecuente la combinación de alteraciones de parámetros urinarios y de suero en hipocitraturia con nefrolitiasis.
Objective: to determine theassociations between nephrolithiasis,citrateandothers metabolites presentinurineand serum of patients with the objective of adapting the diagnosis in care protocols nephrolithiasis. Materials and Methods: descriptive, transversal investigation that included subjects with nephrolithiasis without thiazide therapy, thesample wascomposed of 100 patients who metabolicevaluation was performed in 24-hour uriñe and blood serum samples. The dates were applied descriptive statistics and frequency dispersión and it's compared the frequency of variables with Chi-square. Results:93% of patients with lithiasis had hypocitraturia.The hypernatresiuria occurred in 71.0%, 59.1% had hyperchloremia, the most frequent associations were the hypernatruremia hyperchloremia (50.5%) and hyperuricosuria + hypernatruria (30.1%). Conclusions: exist a high prevalence of hypocitraturia in patients with nephrolithiasis; the condition can occur alone or associated with uriñe biochemical abnormalities blood serum; hyperchloremia more hypermagnesemia is the only dúo blood factors that characterize the patient with nephrolithiasis and hypocitraturia; and often a combination of alteration uriñe parameter and blood serum in patients with nephrolithiasis.
Objective: to determine theassociations between nephrolithiasis,citrateandothers metabolites presentinurineand serum of patients with the objective of adapting the diagnosis in care protocols nephrolithiasis. Materials and Methods: descriptive, transversal investigation that included subjects with nephrolithiasis without thiazide therapy, thesample wascomposed of 100 patients who metabolicevaluation was performed in 24-hour uriñe and blood serum samples. The dates were applied descriptive statistics and frequency dispersión and it's compared the frequency of variables with Chi-square. Results:93% of patients with lithiasis had hypocitraturia.The hypernatresiuria occurred in 71.0%, 59.1% had hyperchloremia, the most frequent associations were the hypernatruremia hyperchloremia (50.5%) and hyperuricosuria + hypernatruria (30.1%). Conclusions: exist a high prevalence of hypocitraturia in patients with nephrolithiasis; the condition can occur alone or associated with uriñe biochemical abnormalities blood serum; hyperchloremia more hypermagnesemia is the only dúo blood factors that characterize the patient with nephrolithiasis and hypocitraturia; and often a combination of alteration uriñe parameter and blood serum in patients with nephrolithiasis.
Description
Vol. 38, No. 2