Comparaison de l'effet de l'exercice physique sur les fonctions plaquettaires et le facteur VIII chez les amérindiens vivant en haute altitude (3600 m) et chez les parisiens

Abstract

Summary. Highlanders natives studied at high altitude (La Paz, 3600 m) were compared with europeans studies at sea level (Paris), using physical exercise as a dynamic model for the investigation of hemostatic and coagulation functions. It was concluded that the thrombocytosis found in men living in chronic hypoxia is not due to a particular redistribution of the platelet vascular pool: - that the thrombocytosis and hyperaggregability following a sub maximal exercise depend on an adrenergic mechanism as at sea level. - that the release of factor VIII from the vascular endothelial cell is independent from the liberation of plasminogen activators - that the liberation of F VIII RA and his activation in F. VIII C could be depending in two different hormonal mechanisms which one possibly linked.