Deep Sequencing of the Trypanosoma cruzi GP63 Surface Proteases Reveals Diversity and Diversifying Selection among Chronic and Congenital Chagas Disease Patients

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dc.contributor.authorMartin Llewellyn
dc.contributor.authorLouisa A. Messenger
dc.contributor.authorAlejandro O. Luquetti
dc.contributor.authorLineth García
dc.contributor.authorFaustino Torrico
dc.contributor.authorSuelene B. N. Tavares
dc.contributor.authorBachar Cheaib
dc.contributor.authorNicolas Derôme
dc.contributor.authorMarc Délepine
dc.contributor.authorCéline Baulard
dc.coverage.spatialBolivia
dc.date.accessioned2026-03-22T14:07:25Z
dc.date.available2026-03-22T14:07:25Z
dc.date.issued2015
dc.descriptionCitaciones: 49
dc.description.abstractOur results shed light on the diversity of parasite DTUs within each patient, as well as the extent to which parasite strains pass between mother and foetus in congenital cases. Although we were unable to find any evidence that parasite diversity accumulates with age in our study cohorts, putative diversifying selection within members of the TcGP63I gene family suggests a link between genetic diversity within this gene family and survival in the mammalian host.
dc.identifier.doi10.1371/journal.pntd.0003458
dc.identifier.urihttps://doi.org/10.1371/journal.pntd.0003458
dc.identifier.urihttps://andeanlibrary.org/handle/123456789/44676
dc.language.isoen
dc.publisherPublic Library of Science
dc.relation.ispartofPLoS neglected tropical diseases
dc.sourceLondon School of Hygiene & Tropical Medicine
dc.subjectBiology
dc.subjectChagas disease
dc.subjectGenetics
dc.subjectTrypanosoma cruzi
dc.subjectContext (archaeology)
dc.subjectLocus (genetics)
dc.titleDeep Sequencing of the Trypanosoma cruzi GP63 Surface Proteases Reveals Diversity and Diversifying Selection among Chronic and Congenital Chagas Disease Patients
dc.typearticle

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