Biomarcadores de metabolismo óseo y su utilidad en la osteoporosis

Abstract

The aim of the work is to describe the main biomarkers of bone metabolism, grouped as: classical (specific, mineralization, formation, and resorption), oxidative stress, and new biomarkers or biomarkers under study, and their usefulness in osteoporosis and other bone diseases. These biomarkers are chemicals secreted primarily by bone cells (osteoblasts and osteoclasts) that are released into the bloodstream and can be determined primarily in the blood and/or urine. Other cells, and even endocrine glands, can produce these substances or compounds. Biomarkers of bone metabolism are the reflection of the dynamics of every bone in our body, as well as the bone turnover. This feature gives them added value and differentiates them from bone densitometry and x-ray, as they provide a static picture of a specific site of the skeleton, for example hip, femur, spine.