Efecto del Lactobacillus rhamnosus GG en la recuperación inmunonutricional de niños desnutridos graves

Abstract

Objectives: to assess the effect of Lactobacillus rhamnosus GG in the recovery of cell mediated immune and nutritional satatus of severely malnourished children. Methods: experimental, randomized, double-blind, controlled in severely malnourished children admitted to the CRIN of the Children’s Hospital Manuel Ascencio Villarroel in Cochabamba, Bolivia. Entered the study with the consent of parents, 44 children with severe malnutrition according to inclusion and exclusion criteria, (21 children study group: 23 children control group). Assessed by anthropometry, psychomotor development, immune response, lymphocyte counting subpopulations CD3, CD1a, CD71 and ultrasonography of the thymus and monitoring with CLAPSEN strategy. The study group received Lactobacillus rhamnosus GG 108/g day in a range of three days and standardized diet with micronutrients. The control group received the same diet and placebo. Data were analyzed with SPSS 19. Results: children in the study group improved P / TZ = 0.71 ± 0.99 SD (p <0.001) IC:95%(1.7- 045), the control group P / TZ =- 1.83 ± 1.15 DE, PBZ,T/ EZ, PCZ with no significant difference. The development of fine motor area: 69.00 ± 15.31 vs. control group: 60.39 ± 14.50 (p ≤ 0.06) IC:95% ( 0.46- 17.68). There was a lower incidence of infections, no significant difference; the recovery time was reduced to 24.28 ± 2.1 days (P≤ 0.001) vs. 33.17 ± 2.80 days of the control group. It was verified Reduction of immature lymphocyte populations with better distribution and greater surface area of thymus 489.61 ± 163.68 vs.. 372.85 ± 84.12 in the control group. Conclusions: Lactobacillus rhamnosus GG, improve and shorten nutritional recovery time and cell-mediate response.