Genetic polymorphism of <i>Trypanosoma cruzi</i> bloodstream populations in adult chronic indeterminate Chagas disease patients from the E1224 clinical trial

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dc.contributor.authorJuan Carlos Ramı́rez
dc.contributor.authorGonzalo R. Acevedo
dc.contributor.authorCarolina Torres
dc.contributor.authorRudy Parrado
dc.contributor.authorAnabelle de la Barra
dc.contributor.authorSandro Villarroel
dc.contributor.authorLineth García
dc.contributor.authorJoaquím Gascón
dc.contributor.authorLourdes Ortiz
dc.contributor.authorFaustino Torrico
dc.coverage.spatialBolivia
dc.date.accessioned2026-03-22T15:10:59Z
dc.date.available2026-03-22T15:10:59Z
dc.date.issued2021
dc.descriptionCitaciones: 5
dc.description.abstractGenetic variability of T. cruzi bloodstream populations during post-treatment follow-up did not differ from that observed during chronic infection in the absence of treatment, suggesting that there were no selection events of E1224-resistant parasite populations. This is the first report documenting the genetic polymorphism of natural T. cruzi populations in chronic patients in the context of clinical trials with trypanocidal drugs.
dc.identifier.doi10.1093/jac/dkab446
dc.identifier.urihttps://doi.org/10.1093/jac/dkab446
dc.identifier.urihttps://andeanlibrary.org/handle/123456789/50865
dc.language.isoen
dc.publisherOxford University Press
dc.relation.ispartofJournal of Antimicrobial Chemotherapy
dc.sourceExperimental Medicine and Biology Institute
dc.subjectMinicircle
dc.subjectBiology
dc.subjectChagas disease
dc.subjectTrypanosoma cruzi
dc.subjectKinetoplast
dc.subjectGenetic variation
dc.subjectGenetics
dc.subjectXenodiagnosis
dc.subjectImmunology
dc.titleGenetic polymorphism of <i>Trypanosoma cruzi</i> bloodstream populations in adult chronic indeterminate Chagas disease patients from the E1224 clinical trial
dc.typearticle

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