Efficacy and safety of delayed thrombolysis for ischemic stroke within 4.5–24 h: A systematic review and meta-analysis of randomized controlled trials

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dc.contributor.authorJesús Fernando Briceño-Domínguez
dc.contributor.authorGrecia Bejarano-Carabeo
dc.contributor.authorRoberto Galvão
dc.contributor.authorBárbara Rodrigues
dc.contributor.authorAlejandro Quintero-Villegas
dc.contributor.authorSergio Iván Valdés‐Ferrer
dc.coverage.spatialBolivia
dc.date.accessioned2026-03-22T21:06:31Z
dc.date.available2026-03-22T21:06:31Z
dc.date.issued2025
dc.description.abstractIn ischemic stroke, thrombolytics administered within 4.5-24h improve functional independence at 90 days, also increasing the risk of symptomatic intracranial hemorrhage. At this point, careful and individualized patient selection, including advanced imaging, is mandatory for thrombolysis beyond the conventional 4.5-h treatment window.
dc.identifier.doi10.1016/j.ric.2025.100030
dc.identifier.urihttps://doi.org/10.1016/j.ric.2025.100030
dc.identifier.urihttps://andeanlibrary.org/handle/123456789/85977
dc.language.isoen
dc.publisherPermanyer
dc.relation.ispartofRevista de investigaci�n Cl�nica
dc.sourceEscola Superior de Ciências da Saúde
dc.subjectMedicine
dc.subjectThrombolysis
dc.subjectRandomized controlled trial
dc.subjectIschemic stroke
dc.subjectStroke (engine)
dc.subjectInternal medicine
dc.subjectCardiology
dc.subjectClinical trial
dc.subjectIntensive care medicine
dc.subjectEmergency medicine
dc.titleEfficacy and safety of delayed thrombolysis for ischemic stroke within 4.5–24 h: A systematic review and meta-analysis of randomized controlled trials
dc.typereview

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