Divergent Macroscopic and Microscopic Patterns in Bony‐Fibrous Entheses Revealed by a Multidisciplinary Approach

Abstract

The study suggests that macroscopic EC grades may not represent successive phases of bone remodeling and adaptation to mechanical loading. Bone growth of entheses with degrees 1 and 2 is gradual, with a compact and well-organized internal anatomy, whereas entheses with degree 3 may result from extreme mechanical stress that triggers intense bone (re)modeling. Micro-CT and histology provided complementary insights, supporting non-destructive methods for future research.