Utilidad del Índice de Pronóstico Inflamatorio y Nutricional (PINI) en el diagnóstico de niños con desnutrición grave

Abstract

Objectives: To evaluate the prognostic inflammatory and nutritional index (PINI) by determining Albumin, Prealbumin, Alpha-1-glyco protein and C-reactive protein as a predictor of risk for nutritional rehabilitation of severely malnourished children. Methods: We studied 36 children (as) in hospitalized malnourished CRIN infected and 30 children (as) controls between 6 months and 5 years with anthropometric and nutritional assessment. Hematological parameters were determined, and nutritional and inflammatory proteins by turbidi metry. The results were expressed as mean ± standard deviation with ANOVA one-way and Student’s t test. 95% statistical confidence (P <0.05) with the statistical package STATA. 10. Results: Anthropometry showed a significant difference in all parameters compared with the control group and reference threshold of the National Center for Health Statistics. Hematologic parameters below the lower limit of normality. 69% with anemia, 19 were deficient transferrin, leukocytosis 25%, 8% eosinophilia, 14% neutrophils and 14% parasitized. The albumin and prealbumin concentrations significantly decreased, the Alpha-1-acid glycoprotein and C-reactive protein significantly hig her than control children (p<0.001). 25% showed a weak risk PINI, 42% moderate risk, high risk 22% and 11% correlated with life-threatening comorbidities. Healthy children, a PINI less than 1. Conclusions: The PINI as a complement to the clinic helps to assess the initial severity of the infection, to foresee and monitor trends in child malnutrition. A micromethod is simple, fast as it can be repeated regularly.