Author response: Specific proteolysis mediated by a p97-directed proteolysis-targeting chimera (p97-PROTAC)

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dc.contributor.authorConstanza Salinas-Rebolledo
dc.contributor.authorJavier Blesa
dc.contributor.authorGuillermo Valenzuela-Nieto
dc.contributor.authorDavid Schwefel
dc.contributor.authorNatalia López-González del Rey
dc.contributor.authorMaxs Méndez-Ruette
dc.contributor.authorJanine Burkhalter
dc.contributor.authorElizabeth Carrazana
dc.contributor.authorFrancisca Díaz-Tejeda
dc.contributor.authorIgnacio Arias Catalán
dc.coverage.spatialBolivia
dc.date.accessioned2026-03-22T21:17:11Z
dc.date.available2026-03-22T21:17:11Z
dc.date.issued2025
dc.description.abstractSynthetic adaptors combining camelid nanobodies with the UBX domain of the p97 adaptor FAF1 enable targeted substrate delivery to p97, establishing an E3 ubiquitin ligase-independent mechanism for selective protein degradation.
dc.identifier.doi10.7554/elife.101496.sa2
dc.identifier.urihttps://doi.org/10.7554/elife.101496.sa2
dc.identifier.urihttps://andeanlibrary.org/handle/123456789/87034
dc.sourceAustral University of Chile
dc.subjectChimera (genetics)
dc.subjectProteolysis
dc.subjectUbiquitin
dc.subjectChemistry
dc.subjectCell biology
dc.subjectSignal transducing adaptor protein
dc.subjectUltrabithorax
dc.subjectAAA proteins
dc.subjectFusion protein
dc.subjectDomain (mathematical analysis)
dc.titleAuthor response: Specific proteolysis mediated by a p97-directed proteolysis-targeting chimera (p97-PROTAC)
dc.typepeer-review

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