An Immunogenetically Defined and Immunodominant Trypanosoma Cruzi Antigen

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dc.contributor.authorR Ramos
dc.contributor.authorM. A. Juri
dc.contributor.authorAlicia Ramos
dc.contributor.authorG Hoecker
dc.contributor.authorSergio Lavandero
dc.contributor.authorPilar de la Peña
dc.contributor.authorAntonio Morello
dc.contributor.authorYolanda Repetto
dc.contributor.authorJuan Carlos Aguillón
dc.contributor.authorA. Ferreira
dc.coverage.spatialBolivia
dc.date.accessioned2026-03-22T14:33:54Z
dc.date.available2026-03-22T14:33:54Z
dc.date.issued1991
dc.descriptionCitaciones: 25
dc.description.abstractTwo strains of mice, A. SW (H-2s) and A.CA (H-2f), were immunized with live trypomastigotes or epimastigotes of the Tulahuen strain of Trypanosoma cruzi or with their sonicates. By immunowestern blotting, sera from A.SW mice, but not from A.CA, recognized, in an immunodominant fashion, a 45 kDal polypeptide (Tc45) present in both epimastigotes and trypomastigotes. Since A.SW and A.CA strains are congenic for the major histocompatibility H-2 complex, recognition of Tc45 seems to be controlled by this genetic region or by gene(s) located in its immediate vicinity. Subcellular fractionation revealed that Tc45 is mainly present at the cytoplasmic compartment.
dc.identifier.doi10.4269/ajtmh.1991.44.314
dc.identifier.urihttps://doi.org/10.4269/ajtmh.1991.44.314
dc.identifier.urihttps://andeanlibrary.org/handle/123456789/47249
dc.language.isoen
dc.publisherAmerican Society of Tropical Medicine and Hygiene
dc.relation.ispartofAmerican Journal of Tropical Medicine and Hygiene
dc.sourceMinistry of Health
dc.subjectTrypanosoma cruzi
dc.subjectAntigen
dc.subjectKinetoplastida
dc.subjectCell fractionation
dc.subjectBiology
dc.subjectEpitope
dc.subjectMolecular biology
dc.subjectCongenic
dc.subjectAmastigote
dc.subjectTrypanosoma
dc.titleAn Immunogenetically Defined and Immunodominant Trypanosoma Cruzi Antigen
dc.typearticle

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