New aporphine alkaloids from Guatteria foliosa

Abstract

Abstract. Four new, alkaloids were obtained from Guatteria foliosa, namely, the noraporphines (--)-3-methoxyputerine [1] and (+)-norguattevaline [2], the more highly oxidized (+)-3-methoxyguattescidine [3], and the oxoaporphine 3-methoxyoxoputerine [4]. Among several other known alkaloids also found in this same plant, (--)-3-hydroxynornuciferine, (--)-isoguattouregidine, and argentinine exhibited significant activity against Trypanosoma cruzi.