EVALUACION DE LA FLORA EN EL VALLE DE ZONGO CONTRA LEISHMANIA Y CHAGAS
Date
Journal Title
Journal ISSN
Volume Title
Publisher
Rev. Bol. Quim
Abstract
Las enfermedades tropicales causadas por protozoos provocan un gran sufrimiento en los países en desarrollo, con elevados radios de morbilidad y mortalidad. Entre estas enfermedades se destacan la Leishmania y el Chagas. La leishmania constituye un grave problema de salud pública por las consecuencias sociales y económicas que conlleva. La OMS ha clasificado a la leishmaniasis, conjuntamente con la tripanosomiasis africana y el dengue, dentro de la categoría 1 para la investigación de nuevos métodos de prevención, diagnóstico y tratamiento [1]. A su vez, la misma organización ha clasificado a la enfermedad del Chagas como la tercera enfermedad tropical más importante a nivel mundial en cuanto a su severidad y mortalidad [2]. El presente trabajo busca especies vegetales con actividades frente a leishmania y chagas. Colectas altitudinales en el valle de Zongo, Bolivia, han presentado dos especies con importantes actividades. La especie Bocconia integrifolia ( Papaveraceae) con un IC50 de 6 µg/ml contra Chagas y 0.4 µg/ml contra tres sepas de leishmania y la especie Liabum hastifolium (Compositae) con un IC50 de 10.4 µg/ml contra tres sepas de leishmania.
Tropical diseases caused by protozoos produce great suffering in developing countries and result in high morbidity and mortality rates. Among these illnesses, Leishmania and Chagas are of importance. Leishmania consists in a critical heath problem for the social and economical consequence that result. Due to these aspects, WHO has classified leishmaniasis, along with African tripanosomiasis and denge, within category 1 for the research of new prevention methods, diagnosis and treatment [1];. In addition, the same organization has classified Chagas disease as the third most important worldwide tropical illness due to its severity and mortality [2] Botanical collects sort by altitude in the Valley of Zongo, Bolivia, have presented two species with important activities. The specie Bocconia integrifolia ( Papaveraceae) with un IC50 of 6 µg/ml against Chagas and 0.4 µg/ml against three strains of leishmania and the specie Liabum hastifolium (Compositae) with un IC50 of 10.4 µg/ml against three strains of leishmania.
Tropical diseases caused by protozoos produce great suffering in developing countries and result in high morbidity and mortality rates. Among these illnesses, Leishmania and Chagas are of importance. Leishmania consists in a critical heath problem for the social and economical consequence that result. Due to these aspects, WHO has classified leishmaniasis, along with African tripanosomiasis and denge, within category 1 for the research of new prevention methods, diagnosis and treatment [1];. In addition, the same organization has classified Chagas disease as the third most important worldwide tropical illness due to its severity and mortality [2] Botanical collects sort by altitude in the Valley of Zongo, Bolivia, have presented two species with important activities. The specie Bocconia integrifolia ( Papaveraceae) with un IC50 of 6 µg/ml against Chagas and 0.4 µg/ml against three strains of leishmania and the specie Liabum hastifolium (Compositae) with un IC50 of 10.4 µg/ml against three strains of leishmania.
Description
Vol. 25, No. 1