MORE INVESTIGATIONS IN POTENT ACTIVITY AND RELATIONSHIP STRUCTURE OF THE LICHEN ANTIBIOTIC (+)-USNIC ACID AND ITS DERIVATE DIBENZOYLUSNIC ACID

Abstract

"By reacting R-(+)-usnic acid (1) with benzoyl chloride in presence of pyridine gave the dibenzoylusnic acid (2). The antibacterial activity and relationship structure of acid usnic an old lichen drug and its derivate dibenzoylusnic acid was studied against nine ATCC bacteria and one bacterium clinical isolate./ Mediante la reacción del R-(+)-acido úsnico con cloruro de benzoilo en presencia de piridina se obtuvo el acido dibenzoilusnico. Se estudio la relación de actividad antibacteriana y estructura del R-(+)-acido úsnico y su derivado el acido dibenzoilúsnico contra nueve bacterias ATCC y una bacteria clínicamente aislada."