When are uncontrolled trials in TB scientifically and ethically justified: Borrowing wisdom from early AIDS clinical trials

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dc.contributor.authorLindsay McKenna
dc.contributor.authorMike Frick
dc.contributor.authorValentina Alarcon-Guizado
dc.contributor.authorGeraint Davies
dc.contributor.authorJennifer Furin
dc.contributor.authorL. Guglielmetti
dc.contributor.authorNorbert Heinrich
dc.contributor.authorMarcus Low
dc.contributor.authorMariama Mahmoud
dc.contributor.authorV. Mave
dc.coverage.spatialBolivia
dc.date.accessioned2026-03-22T20:06:39Z
dc.date.available2026-03-22T20:06:39Z
dc.date.issued2026
dc.description.abstractTuberculosis treatment trials have used various comparison strategies. To inform trial design for novel tuberculosis regimens, we applied an existing framework for evaluating when uncontrolled trials might be justified. We conclude that the conditions are not met for tuberculosis treatment and that uncontrolled phase 3 trials should not be performed.
dc.identifier.doi10.1093/cid/ciag175
dc.identifier.urihttps://doi.org/10.1093/cid/ciag175
dc.identifier.urihttps://andeanlibrary.org/handle/123456789/80046
dc.language.isoen
dc.publisherOxford University Press
dc.relation.ispartofClinical Infectious Diseases
dc.sourceTreatment Action Group
dc.subjectMedicine
dc.subjectClinical trial
dc.subjectTuberculosis
dc.subjectIntensive care medicine
dc.subjectTb treatment
dc.subjectTuberculosis vaccines
dc.subjectMEDLINE
dc.subjectResearch design
dc.subjectAlternative medicine
dc.subjectClinical study design
dc.titleWhen are uncontrolled trials in TB scientifically and ethically justified: Borrowing wisdom from early AIDS clinical trials
dc.typearticle

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