Synthesis of Ring II/III Fragment of Kanamycin: A New Minimum Structural Motif for Aminoglycoside Recognition

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dc.contributor.authorSandra G. Zárate
dc.contributor.authorÁgatha Bastida
dc.contributor.authorAndrés G. Santana
dc.contributor.authorJulia Revuelta
dc.coverage.spatialBolivia
dc.date.accessioned2026-03-22T15:16:40Z
dc.date.available2026-03-22T15:16:40Z
dc.date.issued2019
dc.descriptionCitaciones: 3
dc.description.abstractA novel protocol has been established to prepare the kanamycin ring II/III fragment, which has been validated as a minimum structural motif for the development of new aminoglycosides on the basis of its bactericidal activity even against resistant strains. Furthermore, its ability to act as a AAC-(6') and APH-(3') binder, and as a poor substrate for the ravenous ANT-(4'), makes it an excellent candidate for the design of inhibitors of these aminoglycoside modifying enzymes.
dc.identifier.doi10.3390/antibiotics8030109
dc.identifier.urihttps://doi.org/10.3390/antibiotics8030109
dc.identifier.urihttps://andeanlibrary.org/handle/123456789/51427
dc.language.isoen
dc.publisherMultidisciplinary Digital Publishing Institute
dc.relation.ispartofAntibiotics
dc.sourceUniversity of Saint Francis Xavier
dc.subjectKanamycin
dc.subjectAminoglycoside
dc.subjectChemistry
dc.subjectAntibiotics
dc.subjectFragment (logic)
dc.subjectStereochemistry
dc.subjectMotif (music)
dc.subjectRing (chemistry)
dc.subjectCombinatorial chemistry
dc.titleSynthesis of Ring II/III Fragment of Kanamycin: A New Minimum Structural Motif for Aminoglycoside Recognition
dc.typearticle

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