A Novel Antiprotozoal Aminosteroid from <i>Saracha </i><i>punctata</i>

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dc.contributor.authorChristian Moretti
dc.contributor.authorMichel Sauvain
dc.contributor.authorCatherine Lavaud
dc.contributor.authorGeorges Massiot
dc.contributor.authorJosé A. Bravo
dc.contributor.authorVerónica Francisca Loewe Muñoz
dc.coverage.spatialBolivia
dc.date.accessioned2026-03-22T14:30:05Z
dc.date.available2026-03-22T14:30:05Z
dc.date.issued1998
dc.descriptionCitaciones: 69
dc.description.abstractA new aminosteroid, 3beta-amino-22,26-epiminocholest-5-ene named sarachine (1), and two known flavonoids, eriodictyol (2) and 7-O-beta-D-glucopyranosyl-eriodictyol (3), were isolated from the leaves of Saracha punctata. The alkaloid was found to inhibit the growth of Leishmania braziliensis promastigotes (100% at 25 microM) and of Trypanosoma cruzi epimastigotes in culture (50% at 25 microM) and showed a strong in vitro antiplasmodial activity with an IC50 of 25 nM.
dc.identifier.doi10.1021/np9800654
dc.identifier.urihttps://doi.org/10.1021/np9800654
dc.identifier.urihttps://andeanlibrary.org/handle/123456789/46879
dc.language.isoen
dc.publisherAmerican Chemical Society
dc.relation.ispartofJournal of Natural Products
dc.sourceHigher University of San Andrés
dc.subjectEriodictyol
dc.subjectAntiprotozoal
dc.subjectLeishmania braziliensis
dc.subjectTrypanosoma cruzi
dc.subjectAlkaloid
dc.subjectIn vitro
dc.subjectPharmacognosy
dc.subjectStereochemistry
dc.subjectBiology
dc.subjectLeishmania
dc.titleA Novel Antiprotozoal Aminosteroid from <i>Saracha </i><i>punctata</i>
dc.typearticle

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