POLYOXYGENATED FLAVONOIDS FROM BACCHARIS PENTLANDII

Abstract

Tres flavonoides altamente oxigenados fueron aislados a partir de las hojas de la planta medicinal Baccharis pentlandii D.C. comúnmente conocida como "Chilca clara", "Mayu Chilca" o simplemente "Chilca". Los flavonoides fueron identificados como: 5,4'-dihidroxi-6,7,8,3'-tetrametoxiflavona 8-Metoxicirsilineol (1), 5,4'-dihidroxi-6,7,8-trimetoxiflavona Xantomicrol (2) y 5,3',4'-trihidroxi-6,7,8-trimetoxiflavona Sideritoflavona (3) mediante métodos espectroscópicos. Los compuestos identificados son mayoritarios en la planta y tienen antecedentes como citotóxicos y apoptóticos lo cual confiere a la especie un potencial interés contra el cáncer

Three highly oxygenated flavonoids were isolated from the leaves of the medicinal plant Baccharis pentlandii commonly known as "Chilca clara" Mayu chilca or simply "Chilca". Flavonoids were identified as: 5,4'dihydroxy-6,7,8,3 -tetramethoxyflavone 8-Methoxycirsilineol (1), 5,4'-dihydroxy-6,7,8-trimethoxyflavone Xanthomicrol (2) and 5,3',4'-trihydroxy-6,7,8-trimethoxyflavone Sideritoflavone (3) by spectroscopic methods. The compounds are the major chemical constituents in the plant and they have proved to be cytotoxic as well as apoptotic substances giving thus the species a potential interest against cancer.