A Porous CoII-MOF for CO2 Cycloaddition and the Protective Effect against Staphylococcus aureus Systemic Infection in the Department of Ultrasound

Abstract

A new metal-organic framework (MOF) based on CoII ions as nodes, [Co2(H2O)3(cada)](DMF)4, which has coordinated water molecules at the occupied CoII sites along with a suitable pore environment, was constructed by reaction of 5,5′-(9H-carbazole-2,7-diyl)diisophthalic acid (H4cada) and Co(NO3)2·6H2O in a water and DMF mixed solvent. The resulting activated MOF 1ais able to uptake considerable amounts of CO2 at room temperature, and be further used for the efficient conversion of epoxides along with CO2 into cyclic carbonates under mild conditions without a co-catalyst. To control intra-hospital cross-infection in the Department of Ultrasound, the anti-bacterial activity of the compound was assessed in a systemic Staphylococcus aureus infection mouse model. The survival rate of systemic Staphylococcus aureus infected mice after compound treatment was determined to evaluate protective effect of the compound in vivo. The number of colony-forming units (CFUs) in the organs of infected mice was also counted for further verification.