An intramolecular oxa-Michael reaction on α,β-unsaturated α-amino-δ-hydroxycarboxylic acid esters. Synthesis of functionalized 1,3-dioxanes

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dc.contributor.authorLiliana Becerra‐Figueroa
dc.contributor.authorSantiago Movilla
dc.contributor.authorJoëlle Prunet
dc.contributor.authorGian Pietro Miscione
dc.contributor.authorDiego Gamba‐Sánchez
dc.coverage.spatialBolivia
dc.date.accessioned2026-03-22T14:53:41Z
dc.date.available2026-03-22T14:53:41Z
dc.date.issued2018
dc.descriptionCitaciones: 7
dc.description.abstractA highly diastereoselective intramolecular oxa-Michael reaction on α,β-unsaturated α-amino-δ-hydroxycarboxylic acid esters is presented; 1,3-dioxanes functionalized in positions 2,4 and 6 were obtained in good yields and with excellent selectivities; an experimental and computational study was carried out to understand the reaction course in terms of yields and selectivities. This reaction proceeds under mild reaction conditions using highly electrophilic aldehydes and ketones.
dc.identifier.doi10.1039/c7ob03066e
dc.identifier.urihttps://doi.org/10.1039/c7ob03066e
dc.identifier.urihttps://andeanlibrary.org/handle/123456789/49173
dc.language.isoen
dc.publisherRoyal Society of Chemistry
dc.relation.ispartofOrganic & Biomolecular Chemistry
dc.sourceUniversidad de Los Andes
dc.subjectChemistry
dc.subjectIntramolecular force
dc.subjectMichael reaction
dc.subjectReactivity (psychology)
dc.subjectSelectivity
dc.subjectReaction conditions
dc.subjectCombinatorial chemistry
dc.subjectReaction mechanism
dc.subjectStereochemistry
dc.titleAn intramolecular oxa-Michael reaction on α,β-unsaturated α-amino-δ-hydroxycarboxylic acid esters. Synthesis of functionalized 1,3-dioxanes
dc.typearticle

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