A Model of Extreme Normovolemic Hemodilution in the Conscious Swine to Evaluate Resuscitation Fluids

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dc.contributor.authorJuan David Coronado
dc.contributor.authorSergio David Galvis Forero
dc.contributor.authorAndrew Akbar Shalá Vásquez
dc.contributor.authorJaime Ramón Cabrales Arévalo
dc.contributor.authorPedro Josué Cabrales Arévalo
dc.coverage.spatialBolivia
dc.date.accessioned2026-03-22T16:48:10Z
dc.date.available2026-03-22T16:48:10Z
dc.date.issued2012
dc.description.abstractA model of ENH (Extreme Normovolemic Hemodilution) in the conscious swine was developed. A 4 level blood exchange was performed down to 6% hematocrit. In each level 40% of total blood volume was withdrawn and replaced with the same volume of hydroxyethyl starch. Below hemoglobin (Hb) 3g/dl and 2 hours after last exchange there was tissue hypoxia. 4 of 10 animals survived and only Hb after instrumentation had statistical difference with Hb <10.4 g/dl in non-surviving animals. During ENH there was tissue hypoxia, increase heart rate and cardiac output, divergent blood pressure, decrease oxygen delivery and systemic vascular resistance.
dc.identifier.urihttps://andeanlibrary.org/handle/123456789/60397
dc.language.isoen
dc.sourceUniversidad de Los Andes
dc.subjectHematocrit
dc.subjectHydroxyethyl starch
dc.subjectResuscitation
dc.subjectBlood volume
dc.subjectAnesthesia
dc.subjectHemoglobin
dc.subjectHypoxia (environmental)
dc.subjectHeart rate
dc.subjectMedicine
dc.subjectCardiac output
dc.titleA Model of Extreme Normovolemic Hemodilution in the Conscious Swine to Evaluate Resuscitation Fluids
dc.typearticle

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