Déficit de base y depuración del lactato en el paciente pediátrico con sepsis
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Gac Med Bol
Abstract
El shock séptico genera un estado de falla de aporte de oxígeno y nutrientes a la célula, consiguientemente liberación de productos como el lactato y otros ácidos orgánicos; produciendo un déficit de bases. Objetivo: el presente estudio pretende estimar la correlación del lactato sérico y el déficit de bases como guías en el manejo del shock séptico durante las primeras 24 horas Métodos:se realizó un estudio observacional prospectivo; realizando la medición seriada de lactato y del déficit de base; en pacientes shock séptico tratados de acuerdo a recomendaciones de la Campaña Sobreviviendo a la Sepsis (CSS) 2013. Resultados: el lactato sérico y el déficit de base se depuran en 40% y 5% respectivamente durante las primeras 24 horas; no existe correlación (p=0.289) al ingreso, observándose posteriormente una correlación significativa (p=0,000). Los niveles de depuración en los pacientes fallecidos fueron menores en relación a los sobrevivientes. Conclusiones: el déficit de base no debe ser considerado como un sustituto fiable para el lactato sérico en el paciente con shock séptico; aunque probablemente sea de utilidad después de las 24 horas.
Sepsis and septic shock generate a state of microcirculatory failure, hipoxia and anaerobic metabolism and products like lactic acid and other organic acids are released; which lead to a deficit of bases. Objective: this study aims to estimate the correlation of serum lactate and base deficit as guides in the management of septic shock during the first 24 hours. Method: a prospective observational study; performing serial measurement hours 0, 6, 12 and 24 of lactate and base deficit; in patients with the same scheme of treatment for septic shock recommended by the CSS 2013. Results:the serum lactate and base deficit were modified with resuscitation with a clearance of 40% and 5% respectively; we note that there is no correlation between values (p = 0.289) at Hr. 0; However at 24 hours a significant correlation (P = 0.000) is observed. Conclusions: the base deficit should not be considered a reliable substitute for serum lactate at the beginning of resuscitation of patients with sepsis, severe sepsis and septic shock lactate; but it is likely useful after 24 hours.
Sepsis and septic shock generate a state of microcirculatory failure, hipoxia and anaerobic metabolism and products like lactic acid and other organic acids are released; which lead to a deficit of bases. Objective: this study aims to estimate the correlation of serum lactate and base deficit as guides in the management of septic shock during the first 24 hours. Method: a prospective observational study; performing serial measurement hours 0, 6, 12 and 24 of lactate and base deficit; in patients with the same scheme of treatment for septic shock recommended by the CSS 2013. Results:the serum lactate and base deficit were modified with resuscitation with a clearance of 40% and 5% respectively; we note that there is no correlation between values (p = 0.289) at Hr. 0; However at 24 hours a significant correlation (P = 0.000) is observed. Conclusions: the base deficit should not be considered a reliable substitute for serum lactate at the beginning of resuscitation of patients with sepsis, severe sepsis and septic shock lactate; but it is likely useful after 24 hours.
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Vol. 39, No. 2