Modeling and evaluation of ivermectin release kinetics from 3D-printed tablets.

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dc.contributor.authorBriones Nieva, Cintia Alejandra
dc.contributor.authorReal, Juan Pablo
dc.contributor.authorCampos, Santiago Nicolás
dc.contributor.authorRomero, Analía Irma
dc.contributor.authorVillegas, Mercedes
dc.contributor.authorGonzo, Elio Emilio
dc.contributor.authorBermúdez, José María
dc.contributor.authorPalma, Santiago Daniel
dc.contributor.authorCid, Alicia Graciela
dc.coverage.spatialBolivia
dc.date.accessioned2026-03-24T15:02:50Z
dc.date.available2026-03-24T15:02:50Z
dc.date.issued2024
dc.descriptionVol. 15, No. 11, pp. 845-858
dc.description.abstractAim: This study focused on evaluating the influence of geometric dimensions on the drug release kinetics of 3D-printed tablets.Materials & methods: An ink based on Gelucire 50/13 was prepared to print ivermectin-loaded tablets. The ink was characterized physicochemically and tablet dissolution tests were carried out.Results: The results confirmed the suitability of the ink for 3D printing at a temperature >46°C. Changes in the crystallinity of ivermectin were observed without chemical interactions with the polymer. 3D printed tablets with varied proportional sizes showed dual behavior in their release profiles, while tablets with only thickness reduction exhibited zero-order kinetics.Conclusion: These findings highlight the versatility of 3D printing to create systems with specific and customized release profiles.eng
dc.description.sponsorshipInstituto de Investigaciones para la Industria Química, Universidad Nacional de Salta - Consejo Nacional de Investigaciones Científicas y Técnicas, Av. Bolivia 5150, Salta, 4400, Argentina. | Unidad de Investigación y Desarrollo en Tecnología Farmacéutica, Universidad Nacional de Córdoba - Consejo Nacional de Investigaciones Científicas y Técnicas, Haya de la Torre y Medina Allende, Ciudad Universitaria, Córdoba, 5000, Argentina. | Instituto de Investigaciones para la Industria Química, Universi
dc.identifier.doi10.1080/20415990.2024.2412511
dc.identifier.issn2041-6008
dc.identifier.otherPMID:39434694
dc.identifier.urihttps://doi.org/10.1080/20415990.2024.2412511
dc.identifier.urihttps://andeanlibrary.org/handle/123456789/100888
dc.language.isoeng
dc.relation.ispartofTherapeutic delivery
dc.sourcePubMed
dc.subject3D printing
dc.subjectdrug delivery
dc.subjectgelucire inks
dc.subjectmathematical modeling
dc.subjectpharmaceutical parameters
dc.titleModeling and evaluation of ivermectin release kinetics from 3D-printed tablets.
dc.typeArtículo Científico Publicado

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