SÍNDROME "OVERLAP" HEPATITIS AUTOINMUNE - CIRROSIS BILIAR PRIMARIA. APORTACIÓN DE CASO CLÍNICO

Abstract

El termino "Overlap" describe entidades que comparten características de hepatitis autoinmune y cirrosis biliar primaria o colangítis esclerosante primaria. Se presenta el caso de una paciente mujer, adulta mayor, sin antecedentes de consumo de alcohol ni medicamentos o sustancias hepatotóxicas, con estudios serológicos para hepatitis viral negativos. Clínicamente con signos de hepatopatía crónica. La paciente presenta características clínicas, serológicas, inmunológicas e histológicas mixtas entre Hepatitis Autoinmuney Cirrosis Biliar Primaria, postulándose un síndrome de "sobreposición" u overlap.

The term"overlap sindrome" has been introduced to the field of hepatology to describe variant forms of autoimmune hepatitis (AIH) which present with characteristics of AIH and primary biliary cirrhosis (PBC) or primary sclerosing cholangitis (PSC). We present a case of an elderly female, without past medical history of alcohol, medication or hepatotoxic substances intake, with negative serology studies for viral hepatitis. Clinically with signs of chronic hepatophaty. The patient presents mixed clinical, serologic, immunologic and histologic features of Autoimmune Hepatitis and Primary Biliary Cirrhosis. We postulate this is a variant or overlap syndrome.