WCN24-2644 VITAMIN B COMPLEX IN LIVING KIDNEY DONORS

Abstract

The practice of kidney transplantation enhances the quality of life and improves the rates of survivance in patients with chronical renal diseases. In the case of a kidney transplant with a living donor, different mechanisms are being sought to improve residual renal function. Preclinical studies have identified the upregulation of NAD+ as a potential strategy for the prevention and treatment of AKI (acute kidney injury). NAD+ is the final metabolized form of vitamin B3. A recent clinical study found that COVID-19-related AKI was associated with NAD+ biosynthetic impairment arising in the context of ischemic, inflammatory, or toxic kidney injury.