Mass spectrometry-based discovery and diagnostic validation of T. cruzi antigens in the urine of congenitally infected Chagas Disease patients

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dc.contributor.authorKathryn Cassels
dc.contributor.authorRaghad Almofeez
dc.contributor.authorJessica Roman
dc.contributor.authorHannah Steinberg
dc.contributor.authorAhana Byne
dc.contributor.authorAmanda Haymond
dc.contributor.authorFreddy Tinajeros
dc.contributor.authorMaría del Carmen Menduiña
dc.contributor.authorEdith Málaga
dc.contributor.authorManuela Verástegui
dc.coverage.spatialBolivia
dc.date.accessioned2026-03-22T19:38:24Z
dc.date.available2026-03-22T19:38:24Z
dc.date.issued2025
dc.description.abstractOur work suggests that it is possible to detect Trypanosoma cruzi infection directly from a noninvasively collected fluid such as urine. A direct test in urine with this success rate would be well suited for rapid diagnosis in low-resource areas. Further studies to validate this approach are warranted.
dc.identifier.doi10.1371/journal.pntd.0013082
dc.identifier.urihttps://doi.org/10.1371/journal.pntd.0013082
dc.identifier.urihttps://andeanlibrary.org/handle/123456789/77239
dc.language.isoen
dc.publisherPublic Library of Science
dc.relation.ispartofPLoS neglected tropical diseases
dc.sourceGeorge Mason University
dc.subjectChagas disease
dc.subjectTrypanosoma cruzi
dc.subjectUrine
dc.subjectAntibody
dc.subjectImmunology
dc.subjectAntigen
dc.subjectImmune system
dc.subjectBiology
dc.subjectDisease
dc.subjectMedicine
dc.titleMass spectrometry-based discovery and diagnostic validation of T. cruzi antigens in the urine of congenitally infected Chagas Disease patients
dc.typearticle

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