Comparación de interleucina-6 entre pacientes con Diabetes Mellitus tipo 2 y pacientes con glucosa elevada en ayunas
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Gac Med Bol
Abstract
La prediabetes (glucosa elevada) es un problema médico relativamente común que se supone precede al desarrollo de la diabetes mellitus. Se han realizado numerosos ensayos para predecir la transformación de la prediabetes en diabetes mellitus franca en función de las alteraciones en determinados biomarcadores relacionados con la inflamación. El estudio actual tiene como objetivo estimar la interleucina-6 sérica (IL-6) en individuos con glucosa elevada en ayunas y compararla con la de pacientes con diabetes mellitus tipo 2 de nueva aparición. Métodos: Este estudio transversal inscribió a 159 participantes seleccionados al azar que fueron clasificados igualmente según su historia y hallazgos de laboratorio en grupos de control saludable, prediabetes y diabetes mellitus recién diagnosticada. Se midió la IL-6 sérica en todos los participantes y se comparó y correlacionó estadísticamente con el índice de masa corporal (IMC) y la hemoglobina glucosilada (HbAlc). Resultados: La IL-6 sérica media no mostró diferencias significativas entre los grupos de control y prediabetes, mientras que fue significativamente mayor en el grupo de diabetes en comparación con los grupos de control y prediabetes. Además, se ha revelado una mala correlación entre la IL-6 sérica y la HbAlc. Conclusión: La ausencia de un aumento sostenido de la IL-6 sérica en los 3 grupos estudiados cuestiona su papel beneficioso como predictor de la progresión de la diabetes tipo 2 desde el estado de prediabetes.
Prediabetes is a relatively common medical problem that is supposed to precede the development of diabetes mellitus. Many trials have been performed to predict the transformation of prediabetes into frank diabetes mellitus depending on the alterations in certain biomarkers related to inflammation. The current study aims to estimate serum interleukin-6 (IL-6) in individuals with impaired fasting glucose and compare it to that of patients with new-onset type 2 diabetes mellitus. Methods: This cross-sectional study enrolled 159 randomly selected participants who were equally classified according to their history and laboratory findings into healthy control, prediabetes and newly diagnosed diabetes mellitus groups. Serum IL-6 was measured in all participants and statistically compared and correlated with body mass index (BMI) and glycated hemoglobin (HbA1c). Results: The mean serum IL-6 has shown no significant difference between the control and prediabetes groups while it was significantly higher in the diabetes group compared to both control and prediabetes groups. In addition, a poor correlation has been revealed between serum IL-6 and HbA1c. Conclusión: The absence of a sustained increase in serum IL-6 in the 3 studied groups questions its beneficial role as a predictor of the progression of type 2 diabetes from the prediabetes state.
Prediabetes is a relatively common medical problem that is supposed to precede the development of diabetes mellitus. Many trials have been performed to predict the transformation of prediabetes into frank diabetes mellitus depending on the alterations in certain biomarkers related to inflammation. The current study aims to estimate serum interleukin-6 (IL-6) in individuals with impaired fasting glucose and compare it to that of patients with new-onset type 2 diabetes mellitus. Methods: This cross-sectional study enrolled 159 randomly selected participants who were equally classified according to their history and laboratory findings into healthy control, prediabetes and newly diagnosed diabetes mellitus groups. Serum IL-6 was measured in all participants and statistically compared and correlated with body mass index (BMI) and glycated hemoglobin (HbA1c). Results: The mean serum IL-6 has shown no significant difference between the control and prediabetes groups while it was significantly higher in the diabetes group compared to both control and prediabetes groups. In addition, a poor correlation has been revealed between serum IL-6 and HbA1c. Conclusión: The absence of a sustained increase in serum IL-6 in the 3 studied groups questions its beneficial role as a predictor of the progression of type 2 diabetes from the prediabetes state.
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Vol. 47, No. 2