APPLICATION OF FERRIPROTOPORPHYRIN BIOCRYSTALLIZATION INHIBITION TEST TO FIND ANTIPLASMODIAL COMPOUNDS IN THE FLORA OF THE "ZONGO VALLEY" - BOLIVIA

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dc.contributor.authorIbañez-Calero, Sandra L.
dc.contributor.authorJullian, Valérie
dc.contributor.authorMaurel, Séverine
dc.contributor.authorChavez de Michel, Lia R.
dc.contributor.authorBravo, Jose A.
dc.contributor.authorGimenez, Alberto
dc.contributor.authorSauvain, Michel
dc.coverage.spatialBolivia
dc.date.accessioned2026-03-23T14:52:17Z
dc.date.available2026-03-23T14:52:17Z
dc.date.issued2012
dc.descriptionVol. 29, No. 1
dc.description.abstractAmong the different tests or chemical reactions that explain the possible inhibition mechanisms of Plasmodium falciparum growth, we have chosen the Ferriprotoporphyrin biocrystallization inhibition test (FBIT) to evaluate the pharmacological properties of 65 plants from the Bolivian flora. A bioguided phytochemical separation of Brachyotum microdon, one of the most active plant, was sought using the FBIT test. The isolated active compounds belong to two types of metabolites the fatty alcohols and the triterpenes. Among the triterpenes, we have p-sitosterol (1), oleanolic acid (2), ursolic acid (3) and corosolic acid (4) as sources of the activity on FBIT.en
dc.description.abstractAmong the different tests or chemical reactions that explain the possible inhibition mechanisms of Plasmodium falciparum growth, we have chosen the Ferriprotoporphyrin biocrystallization inhibition test (FBIT) to evaluate the pharmacological properties of 65 plants from the Bolivian flora. A bioguided phytochemical separation of Brachyotum microdon, one of the most active plant, was sought using the FBIT test. The isolated active compounds belong to two types of metabolites the fatty alcohols and the triterpenes. Among the triterpenes, we have p-sitosterol (1), oleanolic acid (2), ursolic acid (3) and corosolic acid (4) as sources of the activity on FBIT.en
dc.identifier.urihttp://www.scielo.org.bo/scielo.php?script=sci_arttext&pid=S0250-54602012000100007&tlng=en
dc.identifier.urihttps://andeanlibrary.org/handle/123456789/89273
dc.language.isoen
dc.publisherRev. Bol. Quim
dc.relationhttp://www.scielo.org.bo/pdf/rbq/v29n1/v29n1a07.pdf
dc.relation.ispartofRev. Bol. Quim
dc.sourceSciELO Bolivia
dc.subjectFerriprotoporphyrin biocrystallization inhibition test
dc.subjectantiplasmodial
dc.subjectBrachyotum microdon
dc.subjectBolivia
dc.titleAPPLICATION OF FERRIPROTOPORPHYRIN BIOCRYSTALLIZATION INHIBITION TEST TO FIND ANTIPLASMODIAL COMPOUNDS IN THE FLORA OF THE "ZONGO VALLEY" - BOLIVIA
dc.title.alternativeAPPLICATION OF FERRIPROTOPORPHYRIN BIOCRYSTALLIZATION INHIBITION TEST TO FIND ANTIPLASMODIAL COMPOUNDS IN THE FLORA OF THE "ZONGO VALLEY" - BOLIVIA
dc.typeArtículo Científico Publicado

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