Antimalarias activity and cytotoxicity of (-)-Roemrefidine isolated from the stem bark of Sparattanthelium amazonum

Muñoz, V

Antimalarias activity and cytotoxicity of (-)-Roemrefidine isolated from the stem bark of Sparattanthelium amazonum

Date

1999

Authors

Muñoz, V

Publisher

Facultad de Medicina, Enfermería, Nutrición y Tecnología Médica

Abstract

Abstract. (-)-Roemrefidine, an aporphine alkaloid isolated from Sparattanthelium amazonum Martius (Hernandiaceae) a vine from Bolivia, has been found to be active against both resistant and sensitive strains of Plasmodium falciparum in vitro and against P. berghei in mice. The compound demonstrated no cytotoxic activity against three cell lines (KB, HEp-2 and HeLa).