Unveiling altered CD8 T-cell metabolism and homeostatic proliferation behind a low CD4/CD8 ratio in ART-suppressed HIV individuals with normal CD4 recovery

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dc.contributor.authorVanesa Garrido‐Rodríguez
dc.contributor.authorÁngel Bulnes‐Ramos
dc.contributor.authorIsrael Olivas-Martínez
dc.contributor.authorMaría del Mar Pozo‐Balado
dc.contributor.authorFrancisco Tejerina
dc.contributor.authorFélix Gutiérrez
dc.contributor.authorCristina Marco‐Sánchez
dc.contributor.authorJuan Tiraboschi
dc.contributor.authorAntonia María Castillo-Navarro
dc.contributor.authorEnrique Bernal
dc.coverage.spatialBolivia
dc.date.accessioned2026-03-22T19:44:20Z
dc.date.available2026-03-22T19:44:20Z
dc.date.issued2025
dc.description.abstractA low CD4/CD8 ratio in chronic PLWH stands on a larger viral reservoir in CD4 T cells and metabolic alterations in CD8 T cells, probably related to its exhaustion and compromised effector functionality, and thymic output could contribute to such alterations. Patients with lower nadir-CD4 showed a resting-like CD4 phenotype and a metabolically active CD8 subset, without further viral reservoir extension. Persistence of low CD4/CD8 ratio and low nadir-CD4 counts seems to rely on different immune damage.
dc.identifier.doi10.3389/fimmu.2025.1617674
dc.identifier.urihttps://doi.org/10.3389/fimmu.2025.1617674
dc.identifier.urihttps://andeanlibrary.org/handle/123456789/77826
dc.language.isoen
dc.publisherFrontiers Media
dc.relation.ispartofFrontiers in Immunology
dc.sourceHospital Universitario Virgen del Rocío
dc.subjectCD4-CD8 Ratio
dc.subjectEffector
dc.subjectCD8
dc.subjectImmune system
dc.subjectHomeostasis
dc.subjectCytotoxic T cell
dc.subjectPhenotype
dc.subjectHuman immunodeficiency virus (HIV)
dc.subjectMetabolism
dc.subjectBiology
dc.titleUnveiling altered CD8 T-cell metabolism and homeostatic proliferation behind a low CD4/CD8 ratio in ART-suppressed HIV individuals with normal CD4 recovery
dc.typearticle

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