Aislamiento y caracterización de (+) - Mellein, la primera isocumarina informó en Stevia género

Abstract

From the acetone extract obtained of leaves and stems of Stevia lucida Lagasca were isolated the following phenolic derivatives: (+)-mellein [1], hispidulin [2], pectolinaringenin [3] and isosakuranetin [4]. These compounds were characterized on the basis of spectroscopic studies, including 1D- and 2D-NMR experiments. The literature review indicated that isocoumarins are rather rare compounds in higher plants. This gives importance to their discovery in the Stevia genus.