Trends of antihypertensive, antidiabetic, and non-steroidal anti-inflammatory drugs use among the Health Workers Cohort Study, Mexico 2004 to 2018.

Abstract

<title>Abstract</title> <italic>Purpose</italic> Hypertension and Type 2 Diabetes (T2D) are the most prevalent non-communicable diseases in Mexico and worldwide. The principal chronic management therapy is daily oral medication according to international practice management guidelines. We aim to describe the trends of the utilization of antihypertensive, antidiabetic, and non-steroidal anti-inflammatories drugs (NSAID) among Mexican adult population from 2004-2018 through three waves. <italic>Methods</italic> We conducted a longitudinal analysis using data from the Health Workers Cohort Study (HWCS), males and females, aged <underline>&gt;</underline> 18 years. The prevalence of chronic diseases and utilization for every kind of antihypertensive, antidiabetic, and NSAIDs (measured by self-reported utilization) were calculated in each of the three study waves, and trends were analyzed using Fisher’s exact test. <italic>Results</italic> Hypertension prevalence increased from 19.8 to 30.3%, same as Diabetes prevalence from 7.0 to 12.8% through fourteen years of follow-up. The proportion of patients using beta-blockers and angiotensin receptor blocker II increased, same as the self-reported dual therapy. Regarding T2D, the prevalence of metformin utilization rose to 83.9%. The utilization of common NSAIDs, mainly for muscular pain, remained around 13 to 16%. <italic>Conclusions</italic> Our findings showed markedly changing utilization drugs prevalence for hypertension and T2D between 2004 and 2018, and consistent utilization of NSAIDs (acetaminophen mainly) in the adult Mexican population.