A intersecção entre programação metabólica, maturação imunológica e terapêutica racional nos primeiros mil dias: uma abordagem pediátrica integrativa

Abstract

This scientific article proposes an in-depth analysis of the physiology of infant development during the first thousand days of life, focusing on the triad: nutrition, immunity, and pharmacology. The research problem addresses how early nutritional intervention and inadequate management of febrile and infectious processes can negatively impact the child's future chronic health. The general objective is to correlate the quality of complementary feeding and the maintenance of gut microbiota homeostasis with immunological competence, advocating for a clinical practice based on the rational use of medications. The methodology is based on a high-level narrative bibliographic review, integrating knowledge of immunology, nutrology, and pharmacodynamics, based on academic guidelines and medical consensus up to 2021. The results indicate that "fever phobia" and inadequate complementary feeding are risk factors for dysbiosis and immune dysregulation. It is concluded that pediatric practice should prioritize health education and environmental modulation over excessive pharmacological intervention, aiming at the primary prevention of atopy and metabolic diseases.