PROGRESSIVE SUPRANUCLEAR PALSY AND DEMENTIA – LITERATURE REVIEW

Abstract

Introduction:Progressive supranuclear palsy is a degenerative disease of the brain, basal ganglia and brainstem, which progressively impairs voluntary eye movements and causes bradykinesia, muscle rigidity with progressive axial dystonia, pseudobulbar palsy and dementia (Hglinger GU, et al, 2017).Objective: Review the relationship between progressive supranuclear palsy and dementia.Result: The first symptoms may be difficulty looking up or down without moving the neck or difficulty going up and down stairs.Movements become slow and axial dystonia develops and patients tend to fall backwards.Repeated falls are common due to postural instability (Hglinger GU, et al., 2017).Conclusion: Dysphagia, dysarthria with emotional lability (pseudobulbar palsy), depression, and disordered sleep are common.Resting tremor may develop.Eventually, dementia occurs.Many patients become disabled within about 5 years and die within approximately 10 years (Adachi M, et al., 2004).