Efectos de la Administración del Clonazepam en la Conducta de Ayuda de Roedores Mus musculus
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Ajayu
Abstract
El presente estudio, exploró la respuesta emocional de ratones Mus musculus, en presencia de un congénere en situación de necesidad, (en cautiverio forzoso), cuando éste realizaba consecuentemente, conductas de liberación del mismo, con y sin la influencia de una benzodiacepina (Clonazepan). Ocho roedores machos, miembros de la misma camada, fueron divididos en parejas y alojados en una cámara experimental, donde uno de ellos se encontraba cautivo y el otro en libertad. En el estudio, se midió el comportamiento (emocional y de rescate o liberación) del roedor libre, a lo largo de 20 sesiones, 10 de ellas en ausencia del fármaco y otras 10 bajo sus efectos. Los resultados indicaron que los roedores llegan a desarrollar conductas emocionales, cuando perciben que un congénere se encuentra en situación crítica, y que son capaces de manifestar comportamientos de ayuda. Se analizó también los efectos inhibitorios de la benzodiacepina sobre tales conductas y se discutió sobre las connotaciones de su efecto.
The present study explored the emotional response of Mus musculus mice, in the presence of a conspecific in need, (in forced captivity), when this consistently performed a release behavior, with and without the influence of a benzodiazepine (Clonazepan). Eight male rodents, members of the same litter, were divided into pairs and housed in an experimental chamber, where one of them was captive and the other was free. In the study, the behavior (emotional and rescue or release) of the free rodent was measured, throughout 20 sessions, 10 of them in the absence of the drug and 10 under its effects. The results indicated that the rodents develop emotional behaviors when they perceive that a congenerate is in a critical situation, and that they are capable of manifesting helpful behaviors. The inhibitory effects of benzodiazepine on such behaviors were also analyzed and the connotations of its effect were discussed.
The present study explored the emotional response of Mus musculus mice, in the presence of a conspecific in need, (in forced captivity), when this consistently performed a release behavior, with and without the influence of a benzodiazepine (Clonazepan). Eight male rodents, members of the same litter, were divided into pairs and housed in an experimental chamber, where one of them was captive and the other was free. In the study, the behavior (emotional and rescue or release) of the free rodent was measured, throughout 20 sessions, 10 of them in the absence of the drug and 10 under its effects. The results indicated that the rodents develop emotional behaviors when they perceive that a congenerate is in a critical situation, and that they are capable of manifesting helpful behaviors. The inhibitory effects of benzodiazepine on such behaviors were also analyzed and the connotations of its effect were discussed.
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Vol. 21, No. 2