Activity of acnistins against Leishmania mexicana, Trypanosoma cruzi and Plasmodium falciparum

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dc.contributor.authorBernardo Chataing
dc.contributor.authorAntoine Hocquette
dc.contributor.authorS.B. Díaz
dc.contributor.authorAlexis Valentin
dc.contributor.authorAlfredo Usubillaga
dc.coverage.spatialBolivia
dc.date.accessioned2026-03-22T15:49:35Z
dc.date.available2026-03-22T15:49:35Z
dc.date.issued2009
dc.descriptionCitaciones: 3
dc.description.abstractAcnistin A and E, two withanolides with a bicyclic side-chain at C-17, isolated from the leaves of Acnitus arborescens (L) Schlecht that grows in the Venezuelan Andes inhibited the growth of Leishmania mexicana and Trypanosoma cruzi in cultured medium. On the other hand acnistins A, E, and L, also inhibited the growth of a chloroquine-resistant strain and a chloroquine-sensitive strain of Plasmodium falciparum in cultured medium. Data indicated that acnistins exerted a higher inhibitory activity upon these parasites that ketoconazole, mevastatin and lapachol in the same conditions of assay.
dc.identifier.urihttps://andeanlibrary.org/handle/123456789/54637
dc.language.isoen
dc.sourceUniversidad de Los Andes
dc.subjectTrypanosoma cruzi
dc.subjectPlasmodium falciparum
dc.subjectLeishmania mexicana
dc.subjectLeishmania
dc.subjectKinetoplastida
dc.subjectKetoconazole
dc.subjectMicrobiology
dc.subjectTrypanosoma
dc.subjectBiology
dc.subjectStrain (injury)
dc.titleActivity of acnistins against Leishmania mexicana, Trypanosoma cruzi and Plasmodium falciparum
dc.typearticle

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