A NEW ANTHRAQUINONE ISOLATED FROM RUMEX OBTUSIFOLIUS

Abstract

"In this research we studied Rumex obtusifolius (Polygonaceae) along with other plants used in traditional medicine in relation to the chemical reaction FBIT (Ferriprotoporphyrine Biocrystallization Inhibition Test) which may provide information on a possible action mechanism for presumed antimalarial plants. According to folk medicine Rumex obtusifolius has a pronounced detoxifying effect on the liver and is used against jaundice and fever. Following a chemical reaction-guided isolation on Rumex obtusifolius we obtained demethylmacrosporine I, an anthraquinone derivative. Its structural determination by one and two dimensional NMR and a proposition of structure-activity relationship are presented."