Proteína C reactiva según el compromiso pulmonar de pacientes COVID-19 a muy alta altitud
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Rev. Inv. Inf. Sal.
Abstract
Introducción: La proteína C reactiva (PCR) es un marcador inmunológico prometedor por su sensibilidad hacia estímulos de inflamación e infección; el objetivo del estudio es determinar el comportamiento de esta según el compromiso pulmonar de pacientes COVID-19, a muy alta altitud. Material y métodos: Estudio observacional, explicativo, transversal, retrospectivo, mediante un muestreo aleatorio simple, se seleccionaron 196 pacientes ingresados al Hospital del Norte de la ciudad de El Alto, con un diagnóstico de neumonía y la prueba RT-PCR positiva. Se realizó un análisis por la prueba chi cuadrado donde la variable dependiente fue el reporte CO-RADS (compromiso pulmonar) y la variable independiente la concentración de la PCR. Resultados: Se observó 58,7 % de varones, con predominio del grupo etario entre 45 a 59 años (34,2 %); media de edad en fallecidos de 54,8 años y con alta 42,2 años; fallecieron 71 pacientes (36,2 %), con un valor de PCR > 23,4 mg/L (grave); un CO-RADS 5 a 6 con 148 pacientes, donde 130 presentaron un valor de PCR grave; por otro lado, a más edad, fallecieron más pacientes; finalmente se encontraron asociaciones estadísticamente significativas entre la concentración de la PCR y el compromiso pulmonar (valor de p = 0,0005). Discusión: Existe una asociación positiva entre las concentraciones de la PCR y el compromiso pulmonar (CO-RADS elevado); de esta manera es posible sugerir el uso de este reactante, en caso de no contar con una tomografía y así evaluar el pronóstico, sobre todo en pacientes a más de 4000 ms.n.m.
Introduction: C-reactive protein (CRP) is a promising immunological marker due to its sensitivity to inflammation and infection stimuli; the objective of the study is to determine its behavior according to the pulmonary compromise of COVID-19 patients, at very high altitude. Material and methods: Observational, explanatory, cross-sectional, retrospective study, through simple random sampling, 196 patients admitted to the Hospital del Norte in the city of El Alto, with a diagnosis of pneumonia and a positive RT-PCR test, were selected. An analysis was performed using the chi-square test where the dependent variable was the CO-RADS report (pulmonary compromise) and the independent variable was the CRP concentration. Results: 58,7 % were men, with a predominance of the age group between 45 and 59 years (34,2 %); average age of deceased 54,8 years and discharged 42,2 years; 71 patients died (36,2 %), with a CRP value > 23,4 mg/L (severe); a CO-RADS 5 to 6 with 148 patients, where 130 had a severe CRP value; on the other hand, the older they were, the more patients died; finally, statistically significant associations were found between CRP concentration and pulmonary involvement (p value = 0,0005). Discussion: There is a positive association between CRP concentrations and pulmonary compromise (high CO-RADS); In this way it is possible to suggest the use of this reactant, if a tomography is not available and thus evaluate the prognosis, especially in patients at more than 4000 msn.m.
Introduction: C-reactive protein (CRP) is a promising immunological marker due to its sensitivity to inflammation and infection stimuli; the objective of the study is to determine its behavior according to the pulmonary compromise of COVID-19 patients, at very high altitude. Material and methods: Observational, explanatory, cross-sectional, retrospective study, through simple random sampling, 196 patients admitted to the Hospital del Norte in the city of El Alto, with a diagnosis of pneumonia and a positive RT-PCR test, were selected. An analysis was performed using the chi-square test where the dependent variable was the CO-RADS report (pulmonary compromise) and the independent variable was the CRP concentration. Results: 58,7 % were men, with a predominance of the age group between 45 and 59 years (34,2 %); average age of deceased 54,8 years and discharged 42,2 years; 71 patients died (36,2 %), with a CRP value > 23,4 mg/L (severe); a CO-RADS 5 to 6 with 148 patients, where 130 had a severe CRP value; on the other hand, the older they were, the more patients died; finally, statistically significant associations were found between CRP concentration and pulmonary involvement (p value = 0,0005). Discussion: There is a positive association between CRP concentrations and pulmonary compromise (high CO-RADS); In this way it is possible to suggest the use of this reactant, if a tomography is not available and thus evaluate the prognosis, especially in patients at more than 4000 msn.m.
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Vol. 19, No. 47