A comparative analysis of the effectiveness of Magnesium Sulfate in treating acute bronchial asthma in children: Nebulized versus intravenous administration.

Abstract

Objective: To compare the mean PRAM score between Nebulized Magnesium Sulphate and IV Magnesium Sulphate in children with acute bronchial asthma.Methodology: This prospective Comparative study was conducted between6th February 2024 to 15th August 2024 at Pediatric ER Dept. PAF Hospital Islamabad. A total of 70 children of acute moderate and severe asthma of either gen-der in age 2 to 12 years old were included. Patients were “divided into two groups”. “Group A” received IV Magnesium Sulfate and “Group B” received nebulized Magnesium Sulphate. PRAM score was recorded at and 60 minutes after the presentation.Results: The mean age of children in Group A was 7.06 ±2.27 & in Group B were 7.66 ±2.44 years. Most of patients 44 (62.8%) were between 7 and 12 years of age. Out of these 70, 43 (62%) males and 27 (38%) females with male to fe-male ratio of 1.6:1. Mean baseline PRAM in Group A was 6.37±1.46 and in Group B was 7.06± 1.55. The mean PRAM at 60 minutes in Group A was 2.63±1.17 and in Group B was 5.31± 1.23 (p value=0.0001)Conclusion: Mean PRAM score is improved with intravenous MgSO4 as compared to nebulized MgSO4 in children pre-senting with acute severe asthma. Keywords: Magnesium sulfate, High dose infusion, Severe asthma, Pediatric Emergency department, PRAM Score