Comparison of Post-Operative Pain After Laparoscopic Cholecystectomy with the Use of Fentanilo or Sufentanilo

Objective: To compare the postoperative analgesic effect, in patients with laparoscopic cholecystectomy under general anesthesia, in which fentanilo vs sufentanilo were used. Material and methods:It was a randomized clinical trial from November 2016 to March 2017 in the Hospital Ángeles Metropolitano.A total of 50 patients that underwent laparoscopic cholecystectomy under general anesthesia were included for analysis and divided in two groups: Group 1 was treated with fentanilo for induction at doses of 3-5 mcg/kg, and maintenance doses of 50-100 mcg every 30 minutes; Group 2: was treated with sufentanilo at doses of 10-15 mcg for induction, and maintenance doses of 10 mcg every 60 minutes.The analgesic effect was analyzed by hemodynamic stability, cardiac frequency changes and arterial blood pressure, and finally visual pain analogue scale.Results: Two groups were analyzed, 1 (fentanilo) and 2(sufentanilo) of 25 patients each one, data about mild, moderate or severe pain was collected at post-operative recovery room incoming, 1 hour, 12 hours and 24 hours after surgery.The incidence and intensity of pain was similar in both groups, without a significant difference, the pain at 12 hours after surgery was higher in both groups although not significant (p <0.05). Conclusion:The postoperative analgesia with diminished doses of sufentanilo during laparoscopic cholecystectomy does not present a real advantage compared with the use of fentanilo in the present study, and present equivalent use of postoperative analgesics.More studies and a bigger sample are needed for a correct comparison of this two drugs in laparoscopic cholecystectomy.